Heartleaf 77 B3 Zinc Trouble Serum
Heartleaf water opens the list and niacinamide is second, declared at 5 percent, with zinc PCA ninth: the three things the name promises are the first, second and ninth entries. Panthenol fourth, gluconolactone and pyridoxine further down. Anua's serum step for congested skin.
No reviews yet- Korean-market formula
- Ships from California or direct from Korea
- Korean barcode and batch code intact
- Suited to
- Congested skinUneven textureDehydrated skinSensitive skin
- Helps with
- Shoppers looking for Exosomes in a serumRoutines that want Exosomes and Niacinamide in one stepFilling the serum step with a Korean-market formula
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- 30-day returns
- Free US shipping on orders of $100 or more
- Tracked delivery to your door
Key benefits
- Exosomes, the active this serum is built around
- Niacinamide, Zinc PCA, Adenosine and Dipotassium Glycyrrhizate on the same list, actives
- Allantoin and Gluconolactone further down the same list
- Capryloyl Salicylic Acid and Pyridoxine HCl further down the same list
- Exosomes named thirtieth on the manufacturer list printed on this page
Key actives
2Niacinamideactive
Niacinamide is vitamin B3, and it is the most studied active in Korean formulation. The panel names it second on this serum's list, beside Exosomes.
10Zinc PCAactive
Zinc PCA pairs zinc with the humectant PCA. It is used in oily and blemish-prone formulas for the look of shine and visible pores, and it hydrates at the same time. The panel names it tenth on this serum's list, beside Exosomes.
20Adenosineactive
Adenosine is a nucleoside that Korea's own cosmetic authority recognises as a wrinkle-care functional ingredient, which is why it appears on so many Korean lists at a low level. It is used for the look of fine lines and is stable and well tolerated. It is named twentieth on this serum's list, alongside Exosomes.
22Dipotassium Glycyrrhizateactive
Dipotassium Glycyrrhizate is a water-soluble salt derived from licorice root. It is named twenty-second on this serum's list, alongside Exosomes.
Exosomesactive
Exosomes are the tiny membrane-bound packets cells release to carry molecules between them. In Korean formulas they are a recent conditioning ingredient, usually plant or ferment derived and declared at very low levels. It is the entry this serum is named after, and the list carries it.
Inside the formula
Inside the formula
- 2Niacinamide
- 10Zinc PCA
- 20Adenosine
- 22Dipotassium Glycyrrhizate
Where each key active sits on the declared ingredient list, by entry number. Position is proportion: the further forward, the larger its share.
Anua Heartleaf 77 B3 Zinc Trouble Serum
Where does this serum go in my routine?
After toner and before moisturizer, morning and evening. Anything thinner than a serum goes on before it, and anything richer goes on after. If you are adding it to a routine you already like, give it a week on its own first, so what you see is the Exosomes and not three changes at once.
What else is on the list besides Exosomes?
Niacinamide, Zinc PCA and Adenosine. The order they are printed in on this serum's panel is the order on the box, so you can see where Exosomes sits relative to them. Further down the same panel: Dipotassium Glycyrrhizate, Allantoin and Gluconolactone.
Not on the ingredient list below: fragrance or parfum, denatured or SD alcohol, essential oils, silicones, parabens, sulfate surfactants, mineral oil or petrolatum and added color.
Full INCI (32): Houttuynia Cordata Flower Leaf Stem Water 77%, Niacinamide 5%, 1, 2 Hexanediol, Panthenol, Glycerin, Dipropylene Glycol, Butylene Glycol, Sodium Citrate, Zinc PCA 1%, Propanediol, Trehalose, Water, Betaine, Xanthan Gum, Sphingomonas Ferment Extract, Ethylhexylglycerin, Citric Acid, Hydroxypropyl Cyclodextrin, Adenosine, Disodium EDTA, Dipotassium Glycyrrhizate, Glyceryl Acrylate Acrylic Acid Copolymer, Gluconolactone, Docosahexaenoic Acid, Tocopherol, Allantoin, Pyridoxine HCl, Capryloyl Salicylic Acid, Houttuynia Cordata Exosome 1.5ppb, Isoquercitrin, Quercetin
Ingredient list read from dodoskin.com on 30 August 2026.
25 of 32 explained
- Panthenol humectant
- Panthenol is pro-vitamin B5: skin converts it to pantothenic acid. It is a humectant that holds water and leaves skin feeling soft and less tight, and it is one of the ingredients formulators reach for when a formula also contains something harsh.
- Glycerin humectant
- Glycerin is the most used humectant in skincare. It draws water into the outer layer of skin and holds it there, and it is one of the very few ingredients whose hydrating effect is settled science rather than marketing. Higher amounts feel tacky, which is why it is usually blended.
- Dipropylene Glycol humectant
- Dipropylene Glycol is a glycol used as a solvent and a light humectant. Its main job is keeping the rest of the formula dissolved and the texture fluid rather than adding hydration of its own.
- Butylene Glycol humectant
- Butylene Glycol is a small glycol that does two jobs at once: it holds water in the top layer of skin and it dissolves plant extracts and actives that plain water cannot. It also thins a formula, which is why watery Korean essences lean on it.
- Sodium Citrate pH adjuster
- Sodium Citrate is the salt of citric acid, used as a buffer: it holds a formula at a steady pH rather than pushing it in one direction. It is also a mild chelator.
- Propanediol humectant
- Propanediol is a plant-derived glycol used in place of propylene glycol. It hydrates, carries actives into solution, and gives a lighter, less sticky slip than glycerin at the same strength.
- Trehalose humectant
- Trehalose is a sugar that some desert plants use to survive drying out. In skincare it is a humectant that holds water in the outer layer and helps a formula feel comfortable rather than tight.
- Water solvent
- Water is the base almost every serum, toner and cream is built on. It dissolves the water-loving ingredients and sets how light the finished texture feels. On an INCI list it is usually first, which only means it is the largest single ingredient by weight.
- Betaine humectant
- Betaine is a sugar-beet-derived humectant that cells use to hold water. In a formula it hydrates and takes the edge off cleansers and acids, which is why it often appears alongside them.
- Xanthan Gum thickener
- Xanthan Gum is a polysaccharide made by fermenting sugar. It thickens a watery formula into a gel and holds the whole thing in suspension so nothing separates. Too much of it and a serum turns stringy, which is why it appears in fractions of a percent.
- Sphingomonas Ferment Extract ferment
- Sphingomonas Ferment Extract is the liquid left after Sphingomonas bacteria have fermented a sugar substrate. It carries water-holding polysaccharides and is used as a conditioning ferment.
- Ethylhexylglycerin preservative booster
- Ethylhexylglycerin softens skin and boosts a preservative system, which is why it is nearly always sitting beside phenoxyethanol or 1,2-hexanediol. It also cuts down the odour bacteria produce, so it turns up in deodorising products.
13 more explained
- Citric Acid pH adjuster
- Citric Acid is used in tiny amounts to bring a formula to the pH its actives need, not as an exfoliant at that level. It is an AHA, so at much higher concentrations it can also exfoliate.
- Hydroxypropyl Cyclodextrin solvent
- Hydroxypropyl Cyclodextrin is a ring-shaped sugar that traps an active molecule inside itself, keeping it stable and releasing it slowly. It is a delivery shell rather than an active.
- Adenosine active
- Adenosine is a nucleoside that Korea's own cosmetic authority recognises as a wrinkle-care functional ingredient, which is why it appears on so many Korean lists at a low level. It is used for the look of fine lines and is stable and well tolerated.
- Disodium EDTA chelator
- EDTA is a chelator: it locks up trace metal ions from water and packaging that would otherwise turn a formula cloudy, off-colour or rancid. It does nothing to skin and appears at a fraction of a percent.
- Dipotassium Glycyrrhizate active
- Dipotassium Glycyrrhizate is a water-soluble salt derived from licorice root. It is the licorice fraction Korean formulas use for the look of redness, and it is far more stable in water than the whole extract.
- Glyceryl Acrylate Acrylic Acid Copolymer film former
- This is a polymer that forms a moisture-holding film on the surface, usually supplied with glycerin and propylene glycol as a hydrating complex.
- Gluconolactone exfoliant
- Gluconolactone is a PHA, the gentlest exfoliant class. Its molecule is too large to penetrate quickly, so it smooths the surface without the sting of an AHA, and it is a humectant at the same time.
- Tocopherol antioxidant
- Tocopherol is vitamin E. It is an oil-soluble antioxidant that protects the oils in a formula from going rancid and works on skin as an emollient, and it is regularly paired with vitamin C because each keeps the other going for longer.
- Allantoin active
- Allantoin is a comfrey-derived compound used to condition skin and soften the outer layer so it feels smoother. It is one of the standard additions to a formula built for easily irritated skin.
- Pyridoxine HCl vitamin
- Pyridoxine HCl is the water-soluble salt of vitamin B6. It is a conditioning vitamin, most often part of a B-complex blend.
- Capryloyl Salicylic Acid exfoliant
- Capryloyl Salicylic Acid is salicylic acid with a fatty tail, sometimes sold as LHA. It stays nearer the surface than salicylic acid and works at a higher pH, so it exfoliates more evenly and more gently.
- Isoquercitrin antioxidant
- Isoquercitrin is quercetin with a glucose unit attached, which makes it far more water soluble than quercetin itself. It is used as a plant flavonoid antioxidant.
- Quercetin antioxidant
- Quercetin is one of the most widespread plant flavonoids, found in onion skin, apple peel and tea. It is a plant antioxidant and is yellow, so it tints a formula.
- Market
- Korean market, the version sold in Korea
- Made in
- Republic of Korea
- Category
- Serum & Ampoule
- Actives
- Adenosine, Allantoin, Heartleaf (Houttuynia Cordata), Licorice Root, Niacinamide, Panthenol, Salicylic Acid, Trehalose, Zinc PCA
- Ships from
- California or Korea
Orders ship from California or direct from Korea with tracked delivery to your door, and both routes carry the same Korean-market release. Shipping is free on orders of $100 or more. Returns are accepted for 30 days, by mail.
We split shipments free, so one out-of-stock item never holds up the rest of your order.
Where this unit came from
- 1Seoul
Bought as Korean-market stock - 2Barcode
Listed against the Korean barcode on its box - 3California or Korea
Ships to you from either, as the same Korean-market release
We stock the version of a formula that is sold in Korea, not the release a brand prepares for another market under the same name.
Every unit keeps its original barcode and batch code intact, so the unit in your hands can be checked against the brand’s own records.
Every order ships from California or direct from Korea, and returns run for 30 days.
Every claim on this page traces to the unit in the box, the barcode, the batch code and the price you can read for yourself.
How it works
The Heartleaf 77 B3 Zinc Trouble Serum is a serum, used after toner and before moisturizer, morning and evening. The active it is built around is Exosomes, named thirtieth on its own ingredient list. The same list carries Niacinamide, Zinc PCA and Adenosine, so the active is not the only thing on it worth naming. How much of the Exosomes stays on the skin, and for how long, is decided by the serum format rather than by the list alone. Anua sells this Exosomes serum in Korea, and this is that version.
How to use
- Use the Heartleaf 77 B3 Zinc Trouble Serum after toner and before moisturizer, morning and evening.
- Three or four drops covers the whole face. Press it in with flat palms instead of rubbing it around.
- Toner first so the surface is damp, then this, then about a minute before your moisturizer goes over the top.
- Twice a day, every day. Do not stack it with a second serum of the same kind; two hydrating serums in one routine do the work of one.
Worth knowing
- Patch test this serum on a small area and wait a day before using it more widely, especially with Exosomes on the list.
- Citric Acid and Gluconolactone on this list makes this serum an exfoliating step, so do not stack it with another one on the same night.
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Anua Heartleaf 77 B3 Zinc Trouble Serum
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Anua, Korean-market original
The Original Korean Formula serum from Anua, formulated with Exosomes and Niacinamide, shipped from California or direct from Korea.
Verify your unit when it arrives
Verify your unit when it arrives
Korean-market stock with the original barcode and batch code intact, exactly as it left Korea.
Anua uses a holographic QR seal that only the HiddenTag app can read. Install HiddenTag from your phone’s app store and scan the seal on the box. A camera app alone will not resolve it.
Source: Anua packaging, HiddenTag scheme
On the unit itself
- The Korean-market barcode, unaltered from the retail package.
- The manufacturer’s batch code, exactly as the maker printed it.
정품Genuine article, Korean-market stock
What professionals say
What professionals say
What skin-care professionals say about the key actives in this formula, quoted from the medical sources linked beside each.
It contains liquiritin, an active compound that helps to disperse and remove existing melanin in the skin.
Jennifer Chwalek, MDDermatologist, Byrdie Niacinamide helps reduce the appearance of pores in a few ways. By strengthening the skin barrier and improving elasticity, pores appear less noticeable and more even.
Ashlyn YankeAesthetician, Cleveland Clinic
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