Manyo Factory
Bifida Biome Complex Ampoule 50ml
Manyo Factory Bifida Biome Complex Ampoule 50ml is an ampoule led by Bifida Ferment Lysate on its own ingredient panel, sourced as the Korean-market formula.
No reviews yet50 ml
$80.00 per 100 ml
- Korean-market formula
- Ships from California or direct from Korea
- Korean barcode and batch code intact
- Suited to
- normalcombinationdryoily
- Helps with
- tone and texture supported by Bifida Ferment Lysatedaily hydration through the ampoule stepa Korean-market formula rather than a US reformulationa routine step matched to this format
In stock. Arrives in 3 to 7 business days
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- 30-day returns
- Free US shipping on orders of $100 or more
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How it works
Bifida Ferment Lysate leads the ingredient panel on this ampoule. Bifida Ferment Lysate is a bifidobacteria ferment with the cells broken open. It is the ingredient behind the first-essence category and is used for the look of tired, reactive skin. On this panel it sits alongside Lactobacillus Ferment Lysate, Lactococcus Ferment Lysate and Saccharomyces Ferment (Kombucha). Lactobacillus Ferment Lysate is the ferment with the bacterial cells broken open, so their contents are in the formula too. It is a conditioning ferment used in barrier-focused products.
Key benefits
- Bifida Ferment Lysate named on this product's own ingredient panel, near the top of it
- Lactobacillus Ferment Lysate on the same panel, the formula's ferment
- Lactococcus Ferment Lysate on the same panel, the formula's ferment
- 50 ml to a unit
- Korean GS1 barcode matched against a Korea sourcing supplier's record for this item
How to use
- Use it as the targeted treatment step, PM, or AM under sunscreen, layered after toner, giving it a moment to settle before the next step.
When in a routine should I use this ampoule?
Use it as the targeted treatment step, PM, or AM under sunscreen, layered after toner. Placing an ampoule out of order is the most common reason a Korean routine feels like it is not working, so keep this one at its own step rather than doubling it up with a product built for a different stage. Give it a few weeks at that placement before judging the result.
Is this the same formula sold in Korea, or a US version?
This is sourced for the Korean market rather than reformulated for US shelves. Manyo Factory sells a separate reformulation on some US shelves, and this listing is not that version. The Korean-market batch coding and packaging travel with it, which is the detail worth checking against the box on arrival.
Where does this formula come from?
It comes from the Korean-market catalog rather than a US-shelf reformulation, and the packaging carries the same Korean-market batch coding a shopper would find on the box in Korea. That sourcing is checked on this row before the page is written, not assumed from the product name. It is the detail worth checking against the box on arrival.
What does Bifida Ferment Lysate do in this formula?
Bifida Ferment Lysate is a fermented ingredient Korean formulas use to condition the surface with a lighter feel than many actives. Fermented ingredients like this are a defining thread of Korean formulation, chosen for a gentler daily-use feel. It sits at its own position on this product's own ingredient list rather than being assumed from the product name.
Not on the ingredient list below: fragrance or parfum, denatured or SD alcohol, essential oils, silicones, parabens, sulfate surfactants, mineral oil or petrolatum and added color.
Full INCI (45): Bifida Ferment Lysate, Butylene Glycol, Bifida Ferment Filtrate, Lactobacillus Ferment Lysate, Lactococcus Ferment Lysate, Saccharomyces Ferment (Kombucha), Glycerin, Niacinamide, 1,2-Hexanediol, Lactobacillus/Pumpkin Fruit Ferment Filtrate, Aureobasidium Pullulans Ferment (Black Fungus), Hyaluronic Acid, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Sodium Acetylated Hyaluronate, Hydrolyzed Sodium Hyaluronate, Potassium Hyaluronate, Hydrolyzed Hyaluronic Acid, Hydroxypropyltrimonium Hyaluronate, Leontopodium Alpinum Callus Culture Extract (Edelweiss), Asiaticoside, Asiatic Acid, Madecassic Acid, Pentylene Glycol, Squalane, Hydrogenated Lecithin, Copper Tripeptide-1, Tromethamine, Acetyl Hexapeptide-8, Propanediol, Ethylhexylglycerin, Dextrin, Water, Caffeine, Benzyl Glycol, Sodium Phytate, Hydrolyzed Algin, Xanthan Gum, Epigallocatechin Gallate (Ecfc/Green Tea), Carbomer, Physalis Alkekengi Calyx Extract (Chinese Lantern), Hydrolyzed Glycosaminoglycans, Polyglyceryl-10 Laurate, Theobroma Cacao (Cocoa) Seed Extract, Adenosine
Ingredient list read from inkeedecoder.com on 10 September 2026.
41 of 45 explained
- Bifida Ferment Lysate ferment
- Bifida Ferment Lysate is a bifidobacteria ferment with the cells broken open. It is the ingredient behind the first-essence category and is used for the look of tired, reactive skin.
- Butylene Glycol humectant
- Butylene Glycol is a small glycol that does two jobs at once: it holds water in the top layer of skin and it dissolves plant extracts and actives that plain water cannot. It also thins a formula, which is why watery Korean essences lean on it.
- Bifida Ferment Filtrate ferment
- Bifida Ferment Filtrate is the liquid strained off a bifidobacteria culture, with the cells filtered out. It is the fraction the first-essence category is built on and is used for the look of tired, reactive skin.
- Lactobacillus Ferment Lysate ferment
- Lactobacillus Ferment Lysate is the ferment with the bacterial cells broken open, so their contents are in the formula too. It is a conditioning ferment used in barrier-focused products.
- Lactococcus Ferment Lysate ferment
- Lactococcus Ferment Lysate is a lactic-culture ferment with the bacterial cells broken open, so their contents are in the formula too. It is used as a conditioning ferment in barrier-focused products.
- Saccharomyces Ferment (Kombucha) ferment
- Saccharomyces Ferment is a brewer's yeast ferment. It supplies amino acids, sugars and B vitamins and is used as a conditioning, hydrating ferment.
- Glycerin humectant
- Glycerin is the most used humectant in skincare. It draws water into the outer layer of skin and holds it there, and it is one of the very few ingredients whose hydrating effect is settled science rather than marketing. Higher amounts feel tacky, which is why it is usually blended.
- Niacinamide active
- Niacinamide is vitamin B3, and it is the most studied active in Korean formulation. It is used at roughly 2 to 5 percent for the look of uneven tone and visible pores, and it is water soluble, stable and comfortable beside almost every other active, which is why it turns up in so many lists.
- 1,2-Hexanediol humectant
- 1,2-Hexanediol is a glycol used for two reasons: it holds water like glycerin, and it makes a formula harder for microbes to live in, so less traditional preservative is needed. Korean formulas use it heavily for that second reason.
- Aureobasidium Pullulans Ferment (Black Fungus) ferment
- A ferment of the yeast-like fungus that pullulan is made from. It yields water-holding beta-glucans and is used as a conditioning ferment.
- Hyaluronic Acid humectant
- Hyaluronic Acid is a sugar chain the body already makes, and one gram of it can hold several litres of water. In a formula it is a humectant that pulls water to the surface of skin and holds it in a film, which is what makes skin look plumper while it is there.
- Sodium Hyaluronate humectant
- Sodium Hyaluronate is the salt of hyaluronic acid, and it is what most products labelled hyaluronic actually contain. The salt dissolves more readily and the molecule is smaller, so it sits in the outer layer of skin rather than only on top of it.
29 more explained
- Sodium Hyaluronate Crosspolymer humectant
- Sodium Hyaluronate Crosspolymer is hyaluronic acid linked into a mesh. It holds water in a soft gel on the surface rather than sinking in, and it releases that water slowly through the day.
- Sodium Acetylated Hyaluronate humectant
- Sodium Acetylated Hyaluronate is hyaluronic acid modified to be part oil-loving, so it clings to skin instead of rinsing away. Formulators call it the one that stays put.
- Hydrolyzed Sodium Hyaluronate humectant
- Hydrolyzed Hyaluronic Acid is hyaluronic acid cut into much shorter fragments. The smaller the fragment, the further into the outer layer it can settle, which is why serums stack several sizes together instead of using one.
- Potassium Hyaluronate humectant
- Potassium Hyaluronate is another salt of hyaluronic acid, used for the same reason as the sodium form: it dissolves easily and holds a large amount of water in the outer layer of skin.
- Hydroxypropyltrimonium Hyaluronate humectant
- Hydroxypropyltrimonium Hyaluronate carries a positive charge, and skin carries a slight negative one, so it is attracted to the surface and stays through rinsing. It is the hyaluronic used where a formula gets washed off.
- Leontopodium Alpinum Callus Culture Extract (Edelweiss) plant extract
- Edelweiss cells grown as a callus culture, then extracted. The alpine plant carries leontopodic acid and other polyphenols, and culture gives a consistent supply without harvesting it.
- Asiaticoside active
- Asiaticoside is one of the four active triterpenes isolated from centella and the most studied of them. Korean formulas name it separately when they want to show which fraction of the plant they standardised.
- Asiatic Acid active
- Asiatic Acid is the third of centella's four triterpenes and the aglycone form, meaning it has no attached sugar. It is oil soluble, so it turns up in cica creams and balms more than in watery layers.
- Madecassic Acid active
- Madecassic Acid is the fourth centella triterpene. A list that names all four is telling you the extract was standardised rather than simply pressed, which is the difference between a cica claim and a cica formula.
- Pentylene Glycol humectant
- Pentylene Glycol hydrates and, like the other longer-chain glycols, makes a formula less hospitable to microbes so the preservative system can be lighter. It also improves how evenly a product spreads.
- Squalane emollient
- Squalane is the stable, saturated version of squalene, a lipid human skin already makes. It is a light emollient that absorbs quickly, does not oxidise, and is one of the few oils widely considered safe for blemish-prone skin. Most cosmetic squalane is now from sugarcane or olive rather than shark.
- Hydrogenated Lecithin emulsifier
- Hydrogenated Lecithin is lecithin with its unsaturated bonds filled in, which makes it far more stable. It emulsifies and is the standard shell for the liposomes that carry actives into the outer layer of skin.
- Copper Tripeptide-1 peptide
- Copper Tripeptide-1 is three amino acids bound to a copper ion, and the classic firming peptide in cosmetic chemistry. It is blue in solution, which is often why a serum carrying it is tinted, and it is used for the look of firmness and fine lines.
- Tromethamine pH adjuster
- Tromethamine neutralises acidic thickeners such as carbomer so they gel, and holds a formula near skin-friendly pH. It is used at a fraction of a percent.
- Acetyl Hexapeptide-8 peptide
- Acetyl Hexapeptide-8 is a six-amino-acid peptide used for the look of expression lines, particularly around the eyes. It is the peptide sold under the name Argireline and is water soluble and stable.
- Propanediol humectant
- Propanediol is a plant-derived glycol used in place of propylene glycol. It hydrates, carries actives into solution, and gives a lighter, less sticky slip than glycerin at the same strength.
- Ethylhexylglycerin preservative booster
- Ethylhexylglycerin softens skin and boosts a preservative system, which is why it is nearly always sitting beside phenoxyethanol or 1,2-hexanediol. It also cuts down the odour bacteria produce, so it turns up in deodorising products.
- Dextrin thickener
- Dextrin is a starch fragment used to thicken and to give a formula a light, powdery finish. It is also a common carrier for powdered extracts.
- Water solvent
- Water is the base almost every serum, toner and cream is built on. It dissolves the water-loving ingredients and sets how light the finished texture feels. On an INCI list it is usually first, which only means it is the largest single ingredient by weight.
- Caffeine active
- Caffeine constricts small blood vessels near the surface, which is why eye products use it for the look of puffiness and shadow. It is water soluble and works only while it is on the skin.
- Benzyl Glycol preservative booster
- Benzyl Glycol is a solvent that also makes a formula less hospitable to microbes, so it appears in preservative blends built without parabens.
- Sodium Phytate chelator
- Sodium Phytate is a rice-derived chelator used in place of EDTA. It ties up trace metals so the formula stays stable and its colour and scent hold.
- Xanthan Gum thickener
- Xanthan Gum is a polysaccharide made by fermenting sugar. It thickens a watery formula into a gel and holds the whole thing in suspension so nothing separates. Too much of it and a serum turns stringy, which is why it appears in fractions of a percent.
- Epigallocatechin Gallate (Ecfc/Green Tea) antioxidant
- Epigallocatechin Gallate, usually written EGCG, is the main catechin in green tea and the compound most green tea claims rest on. It is used as a plant antioxidant.
- Carbomer thickener
- Carbomer is a synthetic polymer that only gels once a base neutralises it, which is why arginine or tromethamine sits nearby on the list. It gives the clear, non-stringy gel texture a xanthan formula cannot reach.
- Hydrolyzed Glycosaminoglycans humectant
- Hydrolyzed Glycosaminoglycans are short fragments of the sugar chains that sit between cells in skin, hyaluronic acid among them. They act as humectants and give a cushioned feel.
- Polyglyceryl-10 Laurate emulsifier
- Polyglyceryl-10 Laurate is a sugar-derived emulsifier and solubiliser, mild enough to be a standard choice in Korean essences. It dissolves small amounts of oil into water without any tightening feel.
- Theobroma Cacao (Cocoa) Seed Extract plant extract
- Cocoa Extract carries polyphenols and a little caffeine. It is used as an antioxidant plant extract and gives a faint warm tint.
- Adenosine active
- Adenosine is a nucleoside that Korea's own cosmetic authority recognises as a wrinkle-care functional ingredient, which is why it appears on so many Korean lists at a low level. It is used for the look of fine lines and is stable and well tolerated.
- Market
- Korean market, the version sold in Korea
- EAN (barcode)
- 8809657114700
- Made in
- Republic of Korea
- Volume
- 50 ml
- Category
- Serum & Ampoule
- Actives
- Adenosine, Caffeine, Centella Asiatica, Hyaluronic Acid, Niacinamide, Peptides, Sodium Hyaluronate, Squalane
- Ships from
- California or Korea
Orders ship from California or direct from Korea with tracked delivery to your door, and both routes carry the same Korean-market release. Shipping is free on orders of $100 or more. Returns are accepted for 30 days, by mail.
We split shipments free, so one out-of-stock item never holds up the rest of your order.
Where this unit came from
- 1Seoul
Bought as Korean-market stock - 2Barcode
Listed against the Korean barcode on its box - 3California or Korea
Ships to you from either, as the same Korean-market release
We stock the version of a formula that is sold in Korea, not the release a brand prepares for another market under the same name. The barcode in the specification above is the Korean-market one and it is printed on the box you receive.
Every unit keeps its original barcode and batch code intact, so the unit in your hands can be checked against the brand’s own records.
Every order ships from California or direct from Korea, and returns run for 30 days.
Every claim on this page traces to the unit in the box, the barcode, the batch code and the price you can read for yourself.
Inside the formula
Inside the formula
Worth knowing
- Patch test on the inner arm first if trying a new brand's formula for the first time.
- Stop use and check the ingredient list against any known sensitivities before continuing.
Complete the routine
- This itemManyo Factory Bifida Biome Complex Ampoule 50ml$40.00
- The treatment step of this routineManyo Factory Galactomy Niacin Essence 50ml$30.00
- Seal the routine in as the last stepManyo Factory Bifida Biome Concentrate Cream 50ml$47.50
Total for 3 items$117.50
Reviews
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Manyo Factory Bifida Biome Complex Ampoule 50ml
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Manyo Factory, Korean-market original
The Korean-market ampoule built around Bifida Ferment Lysate, from Manyo Factory, sourced for the Korean market and reviewed before it ever reaches this page.
Verify your unit when it arrives
Verify your unit when it arrives
Korean-market stock with the original barcode and batch code intact, exactly as it left Korea.
On the unit itself
- The Korean-market barcode, unaltered from the retail package.
- The manufacturer’s batch code, exactly as the maker printed it.
정품Genuine article, Korean-market stock
What professionals say
What professionals say
What skin-care professionals say about skin care, quoted from the medical sources linked beside each.
Your skin barrier is basically your outer layer of the skin.
Melissa Piliang, MDDermatologist, Cleveland Clinic Pretty much every step of a Korean skin care routine is going to have some component of hydration.
Alok Vij, MDDermatologist, Cleveland Clinic
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