DEWYTREE
AC Deep Moisture Barrier Calming Ampoule 60ml
Panthenol fourth, Niacinamide fifth, and below them a barrier set of Ceramide NP, Cholesterol and free linoleic, linolenic and oleic acids, with Sodium DNA and Palmitoyl Hexapeptide-12. 60 ml.
No reviews yet60 ml
$66.67 per 100 ml
- Korean-market formula
- Ships from California or direct from Korea
- Korean barcode and batch code intact
- Suited to
- Dry skinCompromised barrierDehydrated skinSensitive skin
- Helps with
- Shoppers looking for Niacinamide in an ampouleRoutines that want Niacinamide and Sodium DNA in one stepFilling the ampoule step with a Korean-market formula
In stock. Arrives in 3 to 7 business days
We accept
You’re $100.00 away from free US shipping.
- 30-day returns
- Free US shipping on orders of $100 or more
- Tracked delivery to your door
How it works
The AC Deep Moisture Barrier Calming Ampoule is a 60ml ampoule, used after toner and before moisturizer, morning and evening. The active it is built around is Niacinamide, named fifth on its own ingredient list. The same list carries Sodium DNA, Adenosine and Palmitoyl Hexapeptide-12, so the active is not the only thing on it worth naming. How much of the Niacinamide stays on the skin, and for how long, is decided by the ampoule format rather than by the list alone. DEWYTREE sells this Niacinamide ampoule in Korea, and this is that version.
Key benefits
- Niacinamide, the active this ampoule is built around
- Sodium DNA and Adenosine on the same list, actives
- Palmitoyl Hexapeptide-12 on the same list, a peptide
- Tocopherol on the same list, an antioxidant
- Ceramide NP and Cholesterol further down the same list
- Centella Asiatica Extract and Mentha Piperita (Peppermint) Leaf Extract further down the same list
Key actives
5Niacinamideactive
Niacinamide is vitamin B3, and it is the most studied active in Korean formulation. On this ampoule's own ingredient list it is named fifth.
11Sodium DNAactive
Sodium DNA is the salt of DNA, in Korean skincare almost always salmon derived, and it is the ingredient behind the PDRN category. It is used as a humectant and for the look of tired skin; the fragments themselves are what the name PDRN refers to. The panel names it eleventh on this ampoule's list, beside Niacinamide.
13Palmitoyl Hexapeptide-12peptide
Palmitoyl Hexapeptide-12 is a fatted six-amino-acid peptide used for the look of firmness, usually as part of a multi-peptide blend. The panel names it thirteenth on this ampoule's list, beside Niacinamide.
37Adenosineactive
Adenosine is a nucleoside that Korea's own cosmetic authority recognises as a wrinkle-care functional ingredient, which is why it appears on so many Korean lists at a low level. It is used for the look of fine lines and is stable and well tolerated. The panel names it thirty-seventh on this ampoule's list, beside Niacinamide.
44Tocopherolantioxidant
Tocopherol is vitamin E. It is an oil-soluble antioxidant that protects the oils in a formula from going rancid and works on skin as an emollient, and it is regularly paired with vitamin C because each keeps the other going for longer. It is named forty-fourth on this ampoule's list, alongside Niacinamide.
Where does this ampoule go in my routine?
After toner and before moisturizer, morning and evening. Anything thinner than an ampoule goes on before it, and anything richer goes on after. If you are adding it to a routine you already like, give it a week on its own first, so what you see is the Niacinamide and not three changes at once.
What else is on the list besides Niacinamide?
Sodium DNA, Adenosine and Palmitoyl Hexapeptide-12. The order they are printed in on this ampoule's panel is the order on the box, so you can see where Niacinamide sits relative to them. Further down the same panel: Tocopherol, Ceramide NP and Cholesterol.
Not on the ingredient list below: fragrance or parfum, denatured or SD alcohol, essential oils, silicones, parabens, sulfate surfactants, mineral oil or petrolatum and added color.
Full INCI (50): Water, Butylene Glycol, Glycerin, Panthenol, Niacinamide, 1,2-Hexanediol, Macadamia Ternifolia Seed Oil, Pentylene Glycol, Centella Asiatica Extract, Mentha Piperita (Peppermint) Leaf Extract, Sodium Dna, Glycine Soja (Soybean) Peptide, Palmitoyl Hexapeptide-12, Linolenic Acid, Linoleic Acid, Oleic Acid, Squalane, Betula Platyphylla Japonica Juice, Helianthus Annuus (Sunflower) Seed Oil, Ceramide NP, Carthamus Tinctorius (Safflower) Seed Oil, Polyglyceryl-10 Oleate, Salvia Hispanica Seed Oil, Cholesterol, Cetyl Ethylhexanoate, Avena Sativa (Oat) Kernel Extract, Hydrolyzed Hyaluronic Acid, Brassica Campestris (Rapeseed) Sterols, Polyglyceryl-3 Methylglucose Distearate, Glyceryl Stearate, Hydrogenated Polydecene, Jojoba Esters, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Carbomer, Polyquaternium-51, Ethylhexylglycerin, Adenosine, Arginine, Theobroma Cacao (Cocoa) Seed Extract, Sorbitan Isostearate, Sodium Hyaluronate, Sodium Phytate, Coptis Japonica Root Extract, Tocopherol, Candida Bombicola/Glucose/Methyl Rapeseedate Ferment, Dipropylene Glycol, Hydrogenated Lecithin, Caprylyl Glycol, Cetearyl Alcohol, Stearic Acid
Ingredient list read from incidecoder.com on 12 September 2026.
49 of 50 explained
- Water solvent
- Water is the base almost every serum, toner and cream is built on. It dissolves the water-loving ingredients and sets how light the finished texture feels. On an INCI list it is usually first, which only means it is the largest single ingredient by weight.
- Butylene Glycol humectant
- Butylene Glycol is a small glycol that does two jobs at once: it holds water in the top layer of skin and it dissolves plant extracts and actives that plain water cannot. It also thins a formula, which is why watery Korean essences lean on it.
- Glycerin humectant
- Glycerin is the most used humectant in skincare. It draws water into the outer layer of skin and holds it there, and it is one of the very few ingredients whose hydrating effect is settled science rather than marketing. Higher amounts feel tacky, which is why it is usually blended.
- Panthenol humectant
- Panthenol is pro-vitamin B5: skin converts it to pantothenic acid. It is a humectant that holds water and leaves skin feeling soft and less tight, and it is one of the ingredients formulators reach for when a formula also contains something harsh.
- Niacinamide active
- Niacinamide is vitamin B3, and it is the most studied active in Korean formulation. It is used at roughly 2 to 5 percent for the look of uneven tone and visible pores, and it is water soluble, stable and comfortable beside almost every other active, which is why it turns up in so many lists.
- 1,2-Hexanediol humectant
- 1,2-Hexanediol is a glycol used for two reasons: it holds water like glycerin, and it makes a formula harder for microbes to live in, so less traditional preservative is needed. Korean formulas use it heavily for that second reason.
- Macadamia Ternifolia Seed Oil emollient
- Macadamia Seed Oil is unusually high in palmitoleic acid, a fatty acid that human sebum also contains, which is why it absorbs faster than most nut oils. It is a cushioning emollient for dry skin.
- Pentylene Glycol humectant
- Pentylene Glycol hydrates and, like the other longer-chain glycols, makes a formula less hospitable to microbes so the preservative system can be lighter. It also improves how evenly a product spreads.
- Centella Asiatica Extract plant extract
- Centella Asiatica is the plant behind the whole cica category, sold as gotu kola or Madagascar centella. Its extract is the anchor of Korean formulas built for easily reddened skin, and its work is done by four triterpenes: asiaticoside, madecassoside, asiatic acid and madecassic acid.
- Mentha Piperita (Peppermint) Leaf Extract plant extract
- Peppermint leaf extract, the water-based extract rather than the essential oil, so it carries far less menthol. It is used as a refreshing herbal extract.
- Sodium Dna active
- Sodium DNA is the salt of DNA, in Korean skincare almost always salmon derived, and it is the ingredient behind the PDRN category. It is used as a humectant and for the look of tired skin; the fragments themselves are what the name PDRN refers to.
- Palmitoyl Hexapeptide-12 peptide
- Palmitoyl Hexapeptide-12 is a fatted six-amino-acid peptide used for the look of firmness, usually as part of a multi-peptide blend.
37 more explained
- Linolenic Acid fatty acid
- Linolenic Acid is an omega-3 fatty acid from seed oils. It is an emollient and part of the lipid mix skin uses in its own surface layer.
- Linoleic Acid fatty acid
- Linoleic Acid is an essential omega-6 fatty acid and the main fatty acid in sunflower, safflower and rosehip oil. In a formula it is a lipid that softens and sits in the outer layer.
- Oleic Acid fatty acid
- Oleic Acid is the main fatty acid in olive and many nut oils. It is a rich emollient that softens skin and can feel heavy on skin prone to congestion.
- Squalane emollient
- Squalane is the stable, saturated version of squalene, a lipid human skin already makes. It is a light emollient that absorbs quickly, does not oxidise, and is one of the few oils widely considered safe for blemish-prone skin. Most cosmetic squalane is now from sugarcane or olive rather than shark.
- Betula Platyphylla Japonica Juice plant extract
- Betula Platyphylla Japonica Juice is Asian white birch sap, tapped in spring. It is over 98 percent water with trace minerals and sugars, and Korean formulas use it in place of plain water as a hydrating base.
- Helianthus Annuus (Sunflower) Seed Oil emollient
- Sunflower Seed Oil is high in linoleic acid, the fatty acid dry and blemish-prone skin is often short of. It is a light, non-fragrant emollient and one of the better tolerated plant oils.
- Ceramide NP barrier lipid
- Ceramide NP is the most used cosmetic ceramide, the same class of lipid that makes up roughly half the mortar between cells in the outer layer of skin. Added to a cream it slots into that structure, which is why ceramide formulas feel less leaky rather than merely greasy.
- Carthamus Tinctorius (Safflower) Seed Oil emollient
- Safflower seed oil, among the highest-linoleic plant oils. High-linoleic oils feel lighter and absorb faster than high-oleic ones.
- Polyglyceryl-10 Oleate emulsifier
- Polyglyceryl-10 Oleate is a mild sugar-derived emulsifier and solubiliser used where a formula must stay clear.
- Salvia Hispanica Seed Oil emollient
- Chia seed oil, one of the richest plant sources of omega-3 fatty acids. It is a light, fast-absorbing oil that softens skin.
- Cholesterol barrier lipid
- Cholesterol is the third of the three lipids the outer layer of skin is built from, with ceramides and fatty acids. Formulas that carry all three are following the ratio skin itself holds.
- Cetyl Ethylhexanoate emollient
- Cetyl Ethylhexanoate is a synthetic ester used as a dry-feeling emollient. It spreads easily, leaves a silky rather than oily finish, and helps disperse pigments and UV filters evenly.
- Avena Sativa (Oat) Kernel Extract plant extract
- Oat Kernel Extract carries beta-glucan and avenanthramides, and it is one of the most reliably tolerated ingredients in skincare. It is used for the look of reddened, itchy-feeling skin.
- Hydrolyzed Hyaluronic Acid humectant
- Hydrolyzed Hyaluronic Acid is hyaluronic acid cut into much shorter fragments. The smaller the fragment, the further into the outer layer it can settle, which is why serums stack several sizes together instead of using one.
- Brassica Campestris (Rapeseed) Sterols emollient
- Phytosterols are plant sterols, structurally close to the cholesterol in skin's own lipid layer. They soften skin and help the oil phase of a formula hold together.
- Polyglyceryl-3 Methylglucose Distearate emulsifier
- Polyglyceryl-3 Methylglucose Distearate is a sugar-derived emulsifier known for a light, non-soapy feel. It builds gel-creams that do not read as rich.
- Glyceryl Stearate emulsifier
- Glyceryl Stearate is glycerin joined to stearic acid, and one of the most used emulsifiers in skincare. It holds oil and water together and thickens the result, and it softens skin at the same time.
- Hydrogenated Polydecene emollient
- Hydrogenated Polydecene is a synthetic hydrocarbon emollient used in place of mineral oil. It is stable, has no scent, and gives a cushioned slip without oxidising.
- Jojoba Esters emollient
- Jojoba Esters are jojoba wax rebuilt into a softer, meltable form. They condition skin and give body to balms without the heaviness of a butter.
- Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer thickener
- This is the thickener behind most gel-cream textures. It builds a soft, bouncy gel that collapses to a light fluid as it is rubbed in.
- Carbomer thickener
- Carbomer is a synthetic polymer that only gels once a base neutralises it, which is why arginine or tromethamine sits nearby on the list. It gives the clear, non-stringy gel texture a xanthan formula cannot reach.
- Polyquaternium-51 film former
- Polyquaternium-51 is a polymer, sometimes sold as Lipidure, built on the same phosphorylcholine structure as a cell membrane. It holds water in a film on the surface and gives a distinctive soft, dry finish.
- Ethylhexylglycerin preservative booster
- Ethylhexylglycerin softens skin and boosts a preservative system, which is why it is nearly always sitting beside phenoxyethanol or 1,2-hexanediol. It also cuts down the odour bacteria produce, so it turns up in deodorising products.
- Adenosine active
- Adenosine is a nucleoside that Korea's own cosmetic authority recognises as a wrinkle-care functional ingredient, which is why it appears on so many Korean lists at a low level. It is used for the look of fine lines and is stable and well tolerated.
- Arginine amino acid
- Arginine is an amino acid that does two jobs here: it holds water in the outer layer of skin, and it neutralises acidic gelling agents, which is why it often stands in for a synthetic pH adjuster.
- Theobroma Cacao (Cocoa) Seed Extract plant extract
- Cocoa Extract carries polyphenols and a little caffeine. It is used as an antioxidant plant extract and gives a faint warm tint.
- Sorbitan Isostearate emulsifier
- Sorbitan Isostearate is a mild emulsifier that holds water into oil, the direction a cleansing balm or an oil-based cream needs.
- Sodium Hyaluronate humectant
- Sodium Hyaluronate is the salt of hyaluronic acid, and it is what most products labelled hyaluronic actually contain. The salt dissolves more readily and the molecule is smaller, so it sits in the outer layer of skin rather than only on top of it.
- Sodium Phytate chelator
- Sodium Phytate is a rice-derived chelator used in place of EDTA. It ties up trace metals so the formula stays stable and its colour and scent hold.
- Coptis Japonica Root Extract plant extract
- Coptis Japonica is a traditional East Asian medicinal root, bright yellow from its berberine content. In skincare its extract is used for the look of congested, oily skin.
- Tocopherol antioxidant
- Tocopherol is vitamin E. It is an oil-soluble antioxidant that protects the oils in a formula from going rancid and works on skin as an emollient, and it is regularly paired with vitamin C because each keeps the other going for longer.
- Candida Bombicola/Glucose/Methyl Rapeseedate Ferment ferment
- This ferment produces sophorolipids, sugar-based molecules that behave as very mild surfactants and emulsifiers. It is used to keep a formula blended without a harsh cleanser.
- Dipropylene Glycol humectant
- Dipropylene Glycol is a glycol used as a solvent and a light humectant. Its main job is keeping the rest of the formula dissolved and the texture fluid rather than adding hydration of its own.
- Hydrogenated Lecithin emulsifier
- Hydrogenated Lecithin is lecithin with its unsaturated bonds filled in, which makes it far more stable. It emulsifies and is the standard shell for the liposomes that carry actives into the outer layer of skin.
- Caprylyl Glycol preservative booster
- Caprylyl Glycol is a glycol that conditions skin and, more importantly, strengthens a preservative system so less of the traditional preservative is needed. It appears in most modern formulas built without parabens.
- Cetearyl Alcohol fatty alcohol
- Cetearyl Alcohol is a waxy solid, not the drying kind of alcohol. It is a blend of cetyl and stearyl alcohols used to thicken a cream and keep oil and water from separating, and it softens skin as it does so.
- Stearic Acid fatty acid
- Stearic Acid is a saturated fatty acid from plant fats, and one of the three lipid classes skin's own barrier is built from. In a formula it thickens, stabilises the emulsion and can be turned into a soap-style cleanser by adding a base.
- Market
- Korean market, the version sold in Korea
- Made in
- Republic of Korea
- Volume
- 60 ml
- Category
- Serum & Ampoule
- Ships from
- California or Korea
Orders ship from California or direct from Korea with tracked delivery to your door, and both routes carry the same Korean-market release. Shipping is free on orders of $100 or more. Returns are accepted for 30 days, by mail.
We split shipments free, so one out-of-stock item never holds up the rest of your order.
Where this unit came from
- 1Seoul
Bought as Korean-market stock - 2Barcode
Listed against the Korean barcode on its box - 3California or Korea
Ships to you from either, as the same Korean-market release
We stock the version of a formula that is sold in Korea, not the release a brand prepares for another market under the same name.
Every unit keeps its original barcode and batch code intact, so the unit in your hands can be checked against the brand’s own records.
Every order ships from California or direct from Korea, and returns run for 30 days.
Every claim on this page traces to the unit in the box, the barcode, the batch code and the price you can read for yourself.
Inside the formula
Inside the formula
- 5Niacinamide
- 11Sodium DNA
- 37Adenosine
- 44Tocopherol
Where each key active sits on the declared ingredient list, by entry number. Position is proportion: the further forward, the larger its share.
How to use
- Use this serum AM and/or PM, as the serum step, after toner or essence and before moisturizer. Pat or smooth it on rather than rubbing, and give it a moment to settle before layering the next step.
Worth knowing
- Patch test this ampoule on a small area and wait a day before using it more widely, especially with Niacinamide on the list.
- Introduce this ampoule on its own for the first week, so anything your skin does is traceable to the Niacinamide rather than to three changes at once.
Complete the routine
- This itemDEWYTREE AC Deep Moisture Barrier Calming Ampoule 60ml$40.00
- The last step of the morning, over everything elseDEWYTREE Urban Shade Anti-Pollution Tone Up Sun 40ml$25.00
- Seal the routine in as the last stepDEWYTREE ULTRA S4 Snail Cream 80ml$22.50
Total for 3 items$87.50
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DEWYTREE AC Deep Moisture Barrier Calming Ampoule 60ml
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DEWYTREE, Korean-market original
The Original Korean Formula ampoule from DEWYTREE, 60ml formulated with Niacinamide and Sodium DNA, shipped from California or direct from Korea.
Verify your unit when it arrives
Verify your unit when it arrives
Korean-market stock with the original barcode and batch code intact, exactly as it left Korea.
On the unit itself
- The Korean-market barcode, unaltered from the retail package.
- The manufacturer’s batch code, exactly as the maker printed it.
정품Genuine article, Korean-market stock
What professionals say
What professionals say
What skin-care professionals say about the key actives in this formula, quoted from the medical sources linked beside each.
Peptides can be anti-inflammatory, and chronic inflammation damages the tissue in your skin.
Wilma Bergfeld, MDDermatologist, Cleveland Clinic Niacinamide helps reduce the appearance of pores in a few ways. By strengthening the skin barrier and improving elasticity, pores appear less noticeable and more even.
Ashlyn YankeAesthetician, Cleveland Clinic
1 more professional perspective
It's still a very new ingredient in the field of regenerative medicine.
Catherine ChangBeverly Hills board-certified plastic and reconstructive surgeon, Harper's Bazaar
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