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KOREAN PHARMACY

Dr. Althea

345 Relief Cream

A calming cream from Dr. Althea's Korean-market lineup. Niacinamide sits at position 8 of 57 on the brand's own ingredient list, a brightening and barrier-support active; Panthenol follows at position 9, a barrier-support humectant that also settles visible irritation. 50ml to a unit.

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$23.99Comparable US listings run $24.50 (4 dated US observations, checked 10 September 2026)
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Suited to
Dry skinCompromised barrierDehydrated skinSensitive skin
Helps with
Shoppers looking for Niacinamide in a creamRoutines that want Niacinamide and Adenosine in one stepFilling the cream step with a Korean-market formulaAnyone who wants the Niacinamide cream sold on Korean shelves

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How it works

The 345 Relief Cream is a 50ml cream, used as the last skincare step, morning and evening, over serum. The active it is built around is Niacinamide, named seventh on its own ingredient list. The same list carries Adenosine, Oligopeptide-1 and Resveratrol, so the active is not the only thing on it worth naming. How much of the Niacinamide stays on the skin, and for how long, is decided by the cream format rather than by the list alone. This is the Original Korean Formula, the cream Dr.Althea sells in Korea, Niacinamide and all.

Key benefits

  • Niacinamide, the active this cream is built around
  • Adenosine on the same list, an active
  • Oligopeptide-1 on the same list, a peptide
  • Resveratrol and Tocopherol on the same list, antioxidants
  • Ceramide NP and Beta-Glucan further down the same list
  • Laminaria Japonica Extract and Eclipta Prostrata Extract further down the same list

Key actives

Niacinamideactive

Niacinamide is vitamin B3, and it is the most studied active in Korean formulation. On this cream's own ingredient list it is named seventh.

Adenosineactive

Adenosine is a nucleoside that Korea's own cosmetic authority recognises as a wrinkle-care functional ingredient, which is why it appears on so many Korean lists at a low level. It is used for the look of fine lines and is stable and well tolerated. The panel names it forty-sixth on this cream's list, beside Niacinamide.

Oligopeptide-1peptide

Oligopeptide-1 is a short synthetic peptide. Oligo means the chain is short without the name fixing its length, which is why oligopeptides appear in blends where several sequences work together. The panel names it fifty-fourth on this cream's list, beside Niacinamide.

Resveratrolantioxidant

Resveratrol is an antioxidant from grape skin and Japanese knotweed. It is used for the look of dullness and is often paired with ferulic acid, which keeps it stable. The panel names it fifty-first on this cream's list, beside Niacinamide.

Tocopherolantioxidant

Tocopherol is vitamin E. It is an oil-soluble antioxidant that protects the oils in a formula from going rancid and works on skin as an emollient, and it is regularly paired with vitamin C because each keeps the other going for longer. The panel names it fifty-second on this cream's list, beside Niacinamide.

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Dr. Althea 345 Relief Cream

Dr. Althea 345 Relief Cream

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How to use

  1. Use the 345 Relief Cream last in the evening, and under sunscreen in the morning.
  2. A pea-sized amount for the whole face, pressed in rather than rubbed, while skin is still damp from the layer before it.
  3. It goes on after your serum or ampoule. In the morning your sunscreen is the only thing that follows it.
  4. Twice a day, every day. Do not put a water-based layer on top of it, because nothing thin sits well over a seal.

Worth knowing

  • Patch test this cream on a small area and wait a day before using it more widely, especially with Niacinamide on the list.
  • Introduce this cream on its own for the first week, so anything your skin does is traceable to the Niacinamide rather than to three changes at once.

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We’re on gram!

Creators trying on authentic Korean skincare routines and products from us.

  • One month of wearing the Dr. Althea 345 Relief Cream.

    Aasthaetics · YouTube

  • Asking whether the Dr. Althea 345 Relief Cream is worth it.

    alex greyson · YouTube

  • Rating a shelf of Dr. Althea products one by one.

    Jasmine Loo · YouTube

  • Two hydrating serums side by side, IUNIK and Dr. Althea.

    Kristin · YouTube

  • A walk through the Dr. Althea serum lineup and who each one suits.

    auraofmahmuda · YouTube

  • A blunt first take on the Dr. Althea range.

    Lexi Chang · YouTube

  • A first look at the viral 345 Relief Cream before buying.

    Shelley Nayak · YouTube

  • A first try of the Dr. Althea serum on camera.

    Hannah Ziad · YouTube

Dr. Althea, Korean-market original

The Original Korean Formula cream from Dr.Althea, 50ml formulated with Niacinamide and Adenosine, held in the United States and shipped domestically.

Verify your unit when it arrives

Verify your unit when it arrives

Korean-market stock with the original barcode and batch code intact, exactly as it left Korea.

Match the batch code on the box against the code printed on the bottle or tube itself; the two are stamped separately and should agree.

On the unit itself

  • The Korean-market barcode, unaltered from the retail package.
  • The manufacturer’s batch code, exactly as the maker printed it.

정품Genuine article, Korean-market stock

What professionals say

What professionals say

What skin-care professionals say about the key actives in this formula, quoted from the medical sources linked beside each.

  • Peptides can be anti-inflammatory, and chronic inflammation damages the tissue in your skin.

    Wilma Bergfeld, MDDermatologist, Cleveland Clinic
  • Using an antioxidant such as resveratrol helps boost your skin’s natural barriers so that your skin looks and feels smoother and healthier.

    Michele Green, MDBoard-certified dermatologist, Byrdie
1 more professional perspective
  • Niacinamide helps reduce the appearance of pores in a few ways. By strengthening the skin barrier and improving elasticity, pores appear less noticeable and more even.

    Ashlyn YankeAesthetician, Cleveland Clinic

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