IOPE
XMD STEM III Clinical Recovery Serum 50ml
IOPE XMD STEM III Clinical Recovery Serum 50ml is a serum or ampoule built around Niacinamide, named directly on its own Korean-market ingredient list rather than assumed from the product name.
No reviews yet50 ml
$275.00 per 100 ml
- Korean-market formula
- Ships from California or direct from Korea
- Korean barcode and batch code intact
- Suited to
- Dry skinCompromised barrierDehydrated skinSensitive skin
- Helps with
- Shoppers looking for Niacinamide in a serumRoutines that want Niacinamide and Allantoin in one stepFilling the serum step with a Korean-market formula
In stock. Arrives in 3 to 7 business days
We accept
You’re $100.00 away from free US shipping.
- 30-day returns
- Free US shipping on orders of $100 or more
- Tracked delivery to your door
Key benefits
- Niacinamide, the active this serum is built around
- Allantoin, Asiaticoside, Madecassic Acid and Asiatic Acid on the same list, actives
- Adenosine and Hydrolyzed DNA further down the same list
- Acetyl Tetrapeptide-11 and Tocopherol further down the same list
- Niacinamide named fifth on the manufacturer list printed on this page
Key actives
5Niacinamideactive
Niacinamide is vitamin B3, and it is the most studied active in Korean formulation. On this serum's own ingredient list it is named fifth.
15Allantoinactive
Allantoin is a comfrey-derived compound used to condition skin and soften the outer layer so it feels smoother. It is one of the standard additions to a formula built for easily irritated skin. The panel names it fifteenth on this serum's list, beside Niacinamide.
17Asiaticosideactive
Asiaticoside is one of the four active triterpenes isolated from centella and the most studied of them. Korean formulas name it separately when they want to show which fraction of the plant they standardised. It is named seventeenth on this serum's list, alongside Niacinamide.
19Madecassic Acidactive
Madecassic Acid is the fourth centella triterpene. A list that names all four is telling you the extract was standardised rather than simply pressed, which is the difference between a cica claim and a cica formula. The panel names it nineteenth on this serum's list, beside Niacinamide.
23Asiatic Acidactive
Asiatic Acid is the third of centella's four triterpenes and the aglycone form, meaning it has no attached sugar. It is oil soluble, so it turns up in cica creams and balms more than in watery layers. The panel names it twenty-third on this serum's list, beside Niacinamide.
Inside the formula
Inside the formula
- 5Niacinamide
- 15Allantoin
- 17Asiaticoside
- 19Madecassic Acid
- 23Asiatic Acid
Where each key active sits on the declared ingredient list, by entry number. Position is proportion: the further forward, the larger its share.
Where does this serum go in my routine?
After toner and before moisturizer, morning and evening. Anything thinner than a serum goes on before it, and anything richer goes on after. If you are adding it to a routine you already like, give it a week on its own first, so what you see is the Niacinamide and not three changes at once.
What else is on the list besides Niacinamide?
Allantoin, Asiaticoside and Madecassic Acid. The order they are printed in on this serum's panel is the order on the box, so you can see where Niacinamide sits relative to them. Further down the same panel: Asiatic Acid, Adenosine and Hydrolyzed DNA.
Not on the ingredient list below: fragrance or parfum, essential oils, parabens, sulfate surfactants, mineral oil or petrolatum and added color.
Full INCI (32): Water, Butylene Glycol, Glycerin, Dipropylene Glycol, Niacinamide, Betaine, Caprylic/Capric Triglyceride, 1,2-Hexanediol, Dimethicone, Ammonium Acryloyldimethyltaurate/VP Copolymer, Polyglyceryl-6 Caprylate, Polyglyceryl-4 Caprate, Propanediol, Hydrogenated Lecithin, Allantoin, Alcohol, Asiaticoside, Sodium Methyl Stearoyl Taurate, Madecassic Acid, Cholesterol, Mannitol, Chlorella Protothecoides Extract, Asiatic Acid, Ethylhexylglycerin, Adenosine, Hydrolyzed DNA, Dextrin, Hyaluronic Acid, Theobroma Cacao Extract, Allium Cepa (Onion) Bulb Extract, Acetyl Tetrapeptide-11, Tocopherol
Ingredient list read from inkeedecoder.com on 10 September 2026.
31 of 32 explained
- Water solvent
- Water is the base almost every serum, toner and cream is built on. It dissolves the water-loving ingredients and sets how light the finished texture feels. On an INCI list it is usually first, which only means it is the largest single ingredient by weight.
- Butylene Glycol humectant
- Butylene Glycol is a small glycol that does two jobs at once: it holds water in the top layer of skin and it dissolves plant extracts and actives that plain water cannot. It also thins a formula, which is why watery Korean essences lean on it.
- Glycerin humectant
- Glycerin is the most used humectant in skincare. It draws water into the outer layer of skin and holds it there, and it is one of the very few ingredients whose hydrating effect is settled science rather than marketing. Higher amounts feel tacky, which is why it is usually blended.
- Dipropylene Glycol humectant
- Dipropylene Glycol is a glycol used as a solvent and a light humectant. Its main job is keeping the rest of the formula dissolved and the texture fluid rather than adding hydration of its own.
- Niacinamide active
- Niacinamide is vitamin B3, and it is the most studied active in Korean formulation. It is used at roughly 2 to 5 percent for the look of uneven tone and visible pores, and it is water soluble, stable and comfortable beside almost every other active, which is why it turns up in so many lists.
- Betaine humectant
- Betaine is a sugar-beet-derived humectant that cells use to hold water. In a formula it hydrates and takes the edge off cleansers and acids, which is why it often appears alongside them.
- Caprylic/Capric Triglyceride emollient
- Caprylic/Capric Triglyceride is the light fraction of coconut oil, with the heavy parts removed. It is the workhorse emollient of modern formulas: it softens skin, dissolves oil-soluble actives and absorbs without the greasy weight of a whole plant oil.
- 1,2-Hexanediol humectant
- 1,2-Hexanediol is a glycol used for two reasons: it holds water like glycerin, and it makes a formula harder for microbes to live in, so less traditional preservative is needed. Korean formulas use it heavily for that second reason.
- Dimethicone silicone
- Dimethicone is the most used cosmetic silicone. It forms a breathable film that smooths the surface, slows water leaving skin, and gives the slip that makes a primer or cream feel silky. It is inert and does not penetrate.
- Ammonium Acryloyldimethyltaurate/VP Copolymer thickener
- This is a synthetic thickener that gels quickly and holds an emulsion stable across a wide pH range. It gives a light, non-tacky body.
- Polyglyceryl-6 Caprylate emulsifier
- A polyglycerin emulsifier with a short fatty chain, which makes it more water-loving than its longer-chain relatives. It suits cleansing waters and micellar formulas.
- Polyglyceryl-4 Caprate emulsifier
- Polyglyceryl-4 Caprate is a mild sugar-derived solubiliser used to dissolve fragrance and oil into watery formulas.
19 more explained
- Propanediol humectant
- Propanediol is a plant-derived glycol used in place of propylene glycol. It hydrates, carries actives into solution, and gives a lighter, less sticky slip than glycerin at the same strength.
- Hydrogenated Lecithin emulsifier
- Hydrogenated Lecithin is lecithin with its unsaturated bonds filled in, which makes it far more stable. It emulsifies and is the standard shell for the liposomes that carry actives into the outer layer of skin.
- Allantoin active
- Allantoin is a comfrey-derived compound used to condition skin and soften the outer layer so it feels smoother. It is one of the standard additions to a formula built for easily irritated skin.
- Alcohol solvent
- Alcohol here means ethanol. It dissolves ingredients water cannot, evaporates fast so a formula sets quickly and does not feel heavy, and thins texture. In quantity it can leave dry or reactive skin feeling tight, which is why many Korean formulas avoid it and some deliberately use it for a fast, weightless finish.
- Asiaticoside active
- Asiaticoside is one of the four active triterpenes isolated from centella and the most studied of them. Korean formulas name it separately when they want to show which fraction of the plant they standardised.
- Sodium Methyl Stearoyl Taurate surfactant
- A taurine-based surfactant. Taurates foam well while staying mild, and they keep working in hard water where a soap does not.
- Madecassic Acid active
- Madecassic Acid is the fourth centella triterpene. A list that names all four is telling you the extract was standardised rather than simply pressed, which is the difference between a cica claim and a cica formula.
- Cholesterol barrier lipid
- Cholesterol is the third of the three lipids the outer layer of skin is built from, with ceramides and fatty acids. Formulas that carry all three are following the ratio skin itself holds.
- Mannitol humectant
- Mannitol is a sugar alcohol used as a humectant and antioxidant. It hydrates and helps stabilise the rest of the formula against oxidation.
- Asiatic Acid active
- Asiatic Acid is the third of centella's four triterpenes and the aglycone form, meaning it has no attached sugar. It is oil soluble, so it turns up in cica creams and balms more than in watery layers.
- Ethylhexylglycerin preservative booster
- Ethylhexylglycerin softens skin and boosts a preservative system, which is why it is nearly always sitting beside phenoxyethanol or 1,2-hexanediol. It also cuts down the odour bacteria produce, so it turns up in deodorising products.
- Adenosine active
- Adenosine is a nucleoside that Korea's own cosmetic authority recognises as a wrinkle-care functional ingredient, which is why it appears on so many Korean lists at a low level. It is used for the look of fine lines and is stable and well tolerated.
- Hydrolyzed DNA active
- Hydrolyzed DNA is DNA cut into short fragments so it dissolves and spreads. It is the same ingredient family as sodium DNA and polydeoxyribonucleotide, the one Korean formulas market as PDRN.
- Dextrin thickener
- Dextrin is a starch fragment used to thicken and to give a formula a light, powdery finish. It is also a common carrier for powdered extracts.
- Hyaluronic Acid humectant
- Hyaluronic Acid is a sugar chain the body already makes, and one gram of it can hold several litres of water. In a formula it is a humectant that pulls water to the surface of skin and holds it in a film, which is what makes skin look plumper while it is there.
- Theobroma Cacao Extract plant extract
- Cocoa Extract carries polyphenols and a little caffeine. It is used as an antioxidant plant extract and gives a faint warm tint.
- Allium Cepa (Onion) Bulb Extract plant extract
- Onion Bulb Extract carries quercetin and sulphur compounds. Korean formulas use it for the look of blemish marks and uneven tone, and it is the namesake ingredient of the onion skincare line.
- Acetyl Tetrapeptide-11 peptide
- Acetyl Tetrapeptide-11 is a four-amino-acid peptide used for the look of firmness, and it is the usual partner to acetyl tetrapeptide-9.
- Tocopherol antioxidant
- Tocopherol is vitamin E. It is an oil-soluble antioxidant that protects the oils in a formula from going rancid and works on skin as an emollient, and it is regularly paired with vitamin C because each keeps the other going for longer.
- Market
- Korean market, the version sold in Korea
- Made in
- Republic of Korea
- Volume
- 50 ml
- Category
- Serum & Ampoule
- Ships from
- California or Korea
Orders ship from California or direct from Korea with tracked delivery to your door, and both routes carry the same Korean-market release. Shipping is free on orders of $100 or more. Returns are accepted for 30 days, by mail.
We split shipments free, so one out-of-stock item never holds up the rest of your order.
Where this unit came from
- 1Seoul
Bought as Korean-market stock - 2Barcode
Listed against the Korean barcode on its box - 3California or Korea
Ships to you from either, as the same Korean-market release
We stock the version of a formula that is sold in Korea, not the release a brand prepares for another market under the same name.
Every unit keeps its original barcode and batch code intact, so the unit in your hands can be checked against the brand’s own records.
Every order ships from California or direct from Korea, and returns run for 30 days.
Every claim on this page traces to the unit in the box, the barcode, the batch code and the price you can read for yourself.
How it works
The MD STEM III Clinical Recovery Serum is a 50ml serum, used after toner and before moisturizer, morning and evening. The active it is built around is Niacinamide, named fifth on its own ingredient list. The same list carries Allantoin, Asiaticoside and Madecassic Acid, so the active is not the only thing on it worth naming. How much of the Niacinamide stays on the skin, and for how long, is decided by the serum format rather than by the list alone. IOPE sells this Niacinamide serum in Korea, and this is that version.
How to use
- Apply a small amount to cleansed, toned skin, pat in gently, then follow with a moisturizer.
Worth knowing
- Patch test this serum on a small area and wait a day before using it more widely, especially with Niacinamide on the list.
- Introduce this serum on its own for the first week, so anything your skin does is traceable to the Niacinamide rather than to three changes at once.
Complete the routine
- This itemIOPE XMD STEM III Clinical Recovery Serum 50ml$137.50
- Seal the routine in as the last stepIOPE SUPER VITAL EMULSION 150ml$87.50
- The treatment step of this routineIOPE RETINOL RETI-JECTION SERUM 30ml$100.00
Total for 3 items$325.00
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IOPE XMD STEM III Clinical Recovery Serum 50ml
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IOPE, Korean-market original
The Original Korean Formula serum from IOPE, 50ml formulated with Niacinamide and Allantoin, shipped from California or direct from Korea.
Verify your unit when it arrives
Verify your unit when it arrives
Korean-market stock with the original barcode and batch code intact, exactly as it left Korea.
On the unit itself
- The Korean-market barcode, unaltered from the retail package.
- The manufacturer’s batch code, exactly as the maker printed it.
정품Genuine article, Korean-market stock
What professionals say
What professionals say
What skin-care professionals say about the key actives in this formula, quoted from the medical sources linked beside each.
Allantoin can tone down the dryness of the individual cells. It increases the water content of the skin, which means it helps to hydrate and moisturize.
Wilma Bergfeld, MDDermatologist, Cleveland Clinic Centella can make your skin appear more hydrated, plumper and healthier.
Samantha Stein, PA-CDermatology physician assistant, Cleveland Clinic
1 more professional perspective
Niacinamide helps reduce the appearance of pores in a few ways. By strengthening the skin barrier and improving elasticity, pores appear less noticeable and more even.
Ashlyn YankeAesthetician, Cleveland Clinic
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