Mary & May
Spicule Azelaic PDRN Spot Cream
Spicule Azelaic PDRN Spot Cream is Mary & May's cream, a Korean-market formula built around melaleuca alternifolia (tea tree) leaf water named on its own manufacturer ingredient list.
No reviews yet15 g
$6.27 per 10 g
- Korean-market formula
- Ships from California or direct from Korea
- Korean barcode and batch code intact
- Suited to
- Oily skinCombination skinBlemish-prone skin
- Helps with
- A formula built around Melaleuca Alternifolia (Tea Tree) Leaf WaterA last-step moisturising creamA layered Korean routine
In stock. Arrives in 3 to 7 business days
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How it works
Mary & May is a Korean vegan-formula skincare label pitched as an affordable, ingredient-forward routine staple, and Spicule Azelaic PDRN Spot Cream is one of its cream entries. Tea Tree Leaf Oil sits among the first ingredients on the list, the ingredient behind Mediheal's tea-tree line and a long-standing Korean choice for oil-prone, blemish-prone skin. Niacinamide sits within the first ten ingredients, the tone-evening, barrier-supporting active Korean formulas lean on most often, and its early position here means it is not a token dose. Panthenol (pro-vitamin B5) sits in the middle of the ingredient list as the formula's moisture-retention and comfort ingredient, a standard soothing base in Korean-market formulas. Salicylic Acid sits in the middle of the ingredient list, a BHA exfoliant included to keep pores and texture in check. As a cream, it functions as the last skincare step, sealing in what came before in a layered Korean routine. It comes in a 15g format.
Key benefits
- Mary & May's Spicule Azelaic PDRN Spot Cream, sourced for the Korean market rather than reformulated for US shelves
- Formulated around Melaleuca Alternifolia (Tea Tree) Leaf Water, named on the manufacturer's own ingredient list
- Formulated around Niacinamide, named on the manufacturer's own ingredient list
- Formulated around Panthenol, named on the manufacturer's own ingredient list
- Functions as the last skincare step, sealing in what came before
Inside the formula
Inside the formula
What does Melaleuca Alternifolia (Tea Tree) Leaf Water do in this cream?
Tea Tree Leaf Oil sits among the first ingredients on the list, the ingredient behind Mediheal's tea-tree line and a long-standing Korean choice for oil-prone, blemish-prone skin.
Is Niacinamide also in this formula?
Niacinamide sits within the first ten ingredients, the tone-evening, barrier-supporting active Korean formulas lean on most often, and its early position here means it is not a token dose. It sits alongside Melaleuca Alternifolia (Tea Tree) Leaf Water on Mary & May's ingredient list for this product.
How is this cream used in a routine?
Take an amount about the size of a pea and smooth it evenly over the face and neck as the last step of a routine. It works as the last skincare step, sealing in what came before.
Who is this cream suited for?
Oily skin, Combination skin are the best fit for this cream. Patch test on the inner arm before first full use, as with any new skincare product.
Not on the ingredient list below: fragrance or parfum, denatured or SD alcohol, parabens, sulfate surfactants, mineral oil or petrolatum and added color.
Full INCI (69): Water, Melaleuca Alternifolia (Tea Tree) Leaf Water, Propylene Glycol, Niacinamide, Glycerin, Azelaic acid, Dipropylene Glycol, Ammonium Acryloyldimethyltaurate/VP Copolymer, Polypropylsilsesquioxane, Methylpropanediol, Panthenol, Caprylic/Capric Triglyceride, 1,2-Hexanediol, C14-22 Alcohols, Sodium Hydroxide, Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Hydroxyacetophenone, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Glyceryl Stearate, Polyisobutene, Tromethamine, Salicylic Acid, Hydrolyzed Sponge, Zinc PCA, Cetyl Ethylhexanoate, Vinyl Dimethicone, Macadamia Ternifolia Seed Oil, C12-20 Alkyl Glucoside, Brassica Campestris (Rapeseed) Sterols, Polyglyceryl-10 Laurate, Ethylhexylglycerin, Tocopherol, Phytosteryl/Behenyl/Octyldodecyl Lauroyl Glutamate, Cholesterol, Melaleuca Alternifolia (Tea Tree) Leaf Oil, Erythritol, Allantoin, Helianthus Annuus (Sunflower) Seed Oil, Caprylyl/Capryl Glucoside, Butyrospermum Parkii (Shea) Butter, Xanthan Gum, Sorbitan Oleate, Lauryl Glucoside, Hydrogenated Lecithin, Sodium Hyaluronate, Polyglyceryl-6 Laurate, Copper Chlorophyll, Polyglutamic Acid, Myristyl Glucoside, Disodium EDTA, Ceramide NP, Glyceryl Acrylate/Acrylic Acid Copolymer, Madecassoside, Stearic Acid, PVM/MA Copolymer, Magnolol, Honokiol, Rosmarinus Officinalis (Rosemary) Extract, Oleic Acid, Centella Asiatica Extract, Caprylyl Glycol, Butylene Glycol, Sodium DNA, Limonene, Alpha-Terpinene, Hexamethylindanopyran, Pinene, Terpineol, Terpinolene
Ingredient list read from jolse.com on 10 September 2026.
63 of 69 explained
- Water solvent
- Water is the base almost every serum, toner and cream is built on. It dissolves the water-loving ingredients and sets how light the finished texture feels. On an INCI list it is usually first, which only means it is the largest single ingredient by weight.
- Melaleuca Alternifolia (Tea Tree) Leaf Water plant extract
- Tea Tree Leaf Water is the distillate, used in place of plain water as a base. It carries a trace of the plant's aroma and none of the essential oil's strength.
- Propylene Glycol humectant
- Propylene Glycol is a small glycol used as a humectant and solvent. It hydrates and helps actives dissolve; newer formulas often swap it for propanediol, which does the same job with a lighter feel.
- Niacinamide active
- Niacinamide is vitamin B3, and it is the most studied active in Korean formulation. It is used at roughly 2 to 5 percent for the look of uneven tone and visible pores, and it is water soluble, stable and comfortable beside almost every other active, which is why it turns up in so many lists.
- Glycerin humectant
- Glycerin is the most used humectant in skincare. It draws water into the outer layer of skin and holds it there, and it is one of the very few ingredients whose hydrating effect is settled science rather than marketing. Higher amounts feel tacky, which is why it is usually blended.
- Azelaic acid active
- Azelaic Acid is a grain-derived acid used for the look of redness and uneven tone. It is not an exfoliant in the AHA sense and is usually formulated at 10 percent or below in cosmetics.
- Dipropylene Glycol humectant
- Dipropylene Glycol is a glycol used as a solvent and a light humectant. Its main job is keeping the rest of the formula dissolved and the texture fluid rather than adding hydration of its own.
- Ammonium Acryloyldimethyltaurate/VP Copolymer thickener
- This is a synthetic thickener that gels quickly and holds an emulsion stable across a wide pH range. It gives a light, non-tacky body.
- Polypropylsilsesquioxane silicone
- A silicone resin that dries into a hard, water-resistant film. It is what makes a formula stay put through sweat instead of sliding.
- Methylpropanediol humectant
- Methylpropanediol is a small glycol used to hydrate and to help water-soluble actives penetrate the outer layer of skin more evenly. It leaves almost no tack, which suits watery textures.
- Panthenol humectant
- Panthenol is pro-vitamin B5: skin converts it to pantothenic acid. It is a humectant that holds water and leaves skin feeling soft and less tight, and it is one of the ingredients formulators reach for when a formula also contains something harsh.
- Caprylic/Capric Triglyceride emollient
- Caprylic/Capric Triglyceride is the light fraction of coconut oil, with the heavy parts removed. It is the workhorse emollient of modern formulas: it softens skin, dissolves oil-soluble actives and absorbs without the greasy weight of a whole plant oil.
51 more explained
- 1,2-Hexanediol humectant
- 1,2-Hexanediol is a glycol used for two reasons: it holds water like glycerin, and it makes a formula harder for microbes to live in, so less traditional preservative is needed. Korean formulas use it heavily for that second reason.
- C14-22 Alcohols fatty alcohol
- C14-22 Alcohols is a declaration for a mixture of long-chain fatty alcohols. They thicken a cream and hold the emulsion together.
- Sodium Hydroxide pH adjuster
- Sodium Hydroxide is a strong base used in traces to bring an acidic formula up to skin-friendly pH. None of it remains as itself once the formula is neutralised.
- Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer thickener
- This is a pre-neutralised polymer thickener that gels on contact with water and stabilises an emulsion without heat.
- Hydroxyacetophenone preservative booster
- Hydroxyacetophenone is an antioxidant that also strengthens a preservative system, so a formula needs less traditional preservative. Korean formulas pair it with 1,2-hexanediol constantly.
- Acrylates/C10-30 Alkyl Acrylate Crosspolymer thickener
- This is a carbomer relative with fatty side chains, so it thickens and stabilises an emulsion at the same time. It gives a light gel-cream body rather than a heavy one.
- Glyceryl Stearate emulsifier
- Glyceryl Stearate is glycerin joined to stearic acid, and one of the most used emulsifiers in skincare. It holds oil and water together and thickens the result, and it softens skin at the same time.
- Polyisobutene film former
- Polyisobutene is a synthetic polymer that forms a flexible, water-resistant film. It gives gloss and holds a formula in place, which is why it appears in lip products and long-wear textures.
- Tromethamine pH adjuster
- Tromethamine neutralises acidic thickeners such as carbomer so they gel, and holds a formula near skin-friendly pH. It is used at a fraction of a percent.
- Salicylic Acid exfoliant
- Salicylic Acid is a BHA, and the only common exfoliant that is oil soluble, so it can work inside a pore rather than only on the surface. It loosens the dead cells that block pores and is used for the look of congested, oily skin.
- Hydrolyzed Sponge active
- Hydrolyzed Sponge is processed freshwater sponge, which carries fine silica spicules. In a formula it works as a mild physical exfoliant.
- Zinc PCA active
- Zinc PCA pairs zinc with the humectant PCA. It is used in oily and blemish-prone formulas for the look of shine and visible pores, and it hydrates at the same time.
- Cetyl Ethylhexanoate emollient
- Cetyl Ethylhexanoate is a synthetic ester used as a dry-feeling emollient. It spreads easily, leaves a silky rather than oily finish, and helps disperse pigments and UV filters evenly.
- Vinyl Dimethicone silicone
- Vinyl Dimethicone is a silicone used as a building block of the crosspolymer gels that give a formula its soft, blurring feel.
- Macadamia Ternifolia Seed Oil emollient
- Macadamia Seed Oil is unusually high in palmitoleic acid, a fatty acid that human sebum also contains, which is why it absorbs faster than most nut oils. It is a cushioning emollient for dry skin.
- C12-20 Alkyl Glucoside emulsifier
- C12-20 Alkyl Glucoside is a sugar-derived emulsifier used in mild, plant-based cream bases.
- Brassica Campestris (Rapeseed) Sterols emollient
- Phytosterols are plant sterols, structurally close to the cholesterol in skin's own lipid layer. They soften skin and help the oil phase of a formula hold together.
- Polyglyceryl-10 Laurate emulsifier
- Polyglyceryl-10 Laurate is a sugar-derived emulsifier and solubiliser, mild enough to be a standard choice in Korean essences. It dissolves small amounts of oil into water without any tightening feel.
- Ethylhexylglycerin preservative booster
- Ethylhexylglycerin softens skin and boosts a preservative system, which is why it is nearly always sitting beside phenoxyethanol or 1,2-hexanediol. It also cuts down the odour bacteria produce, so it turns up in deodorising products.
- Tocopherol antioxidant
- Tocopherol is vitamin E. It is an oil-soluble antioxidant that protects the oils in a formula from going rancid and works on skin as an emollient, and it is regularly paired with vitamin C because each keeps the other going for longer.
- Phytosteryl/Behenyl/Octyldodecyl Lauroyl Glutamate barrier lipid
- An amino-acid-based lipid built on plant sterols. It structures the oil phase of a cream and echoes the lipid mix that already sits between skin cells.
- Cholesterol barrier lipid
- Cholesterol is the third of the three lipids the outer layer of skin is built from, with ceramides and fatty acids. Formulas that carry all three are following the ratio skin itself holds.
- Melaleuca Alternifolia (Tea Tree) Leaf Oil fragrance component
- Tea Tree Leaf Oil is an essential oil from an Australian shrub, carrying terpinen-4-ol. Korean formulas use it in products aimed at blemish-prone skin; it is potent, aromatic, and one of the essential oils most likely to bother reactive skin.
- Erythritol humectant
- Erythritol is a sugar alcohol humectant with a faint cooling feel as it dissolves. It hydrates and helps a formula spread without tack.
- Allantoin active
- Allantoin is a comfrey-derived compound used to condition skin and soften the outer layer so it feels smoother. It is one of the standard additions to a formula built for easily irritated skin.
- Helianthus Annuus (Sunflower) Seed Oil emollient
- Sunflower Seed Oil is high in linoleic acid, the fatty acid dry and blemish-prone skin is often short of. It is a light, non-fragrant emollient and one of the better tolerated plant oils.
- Caprylyl/Capryl Glucoside surfactant
- Caprylyl/Capryl Glucoside is a sugar-derived cleansing surfactant. It foams modestly and is mild enough for low-pH cleansers built for reactive skin.
- Butyrospermum Parkii (Shea) Butter emollient
- Shea Butter is the fat pressed from the shea nut, rich in oleic and stearic acids and unsaponifiable plant sterols. It is a heavy emollient and partial occlusive, which is why it sits in balms and night creams rather than in essences.
- Xanthan Gum thickener
- Xanthan Gum is a polysaccharide made by fermenting sugar. It thickens a watery formula into a gel and holds the whole thing in suspension so nothing separates. Too much of it and a serum turns stringy, which is why it appears in fractions of a percent.
- Sorbitan Oleate emulsifier
- Sorbitan Oleate is an emulsifier for water-in-oil formulas. It keeps a rich cream or a cleansing oil from separating.
- Lauryl Glucoside surfactant
- A sugar surfactant made from glucose and a fatty alcohol. Glucosides carry no charge, which is what makes them mild, and they give a soft low foam.
- Hydrogenated Lecithin emulsifier
- Hydrogenated Lecithin is lecithin with its unsaturated bonds filled in, which makes it far more stable. It emulsifies and is the standard shell for the liposomes that carry actives into the outer layer of skin.
- Sodium Hyaluronate humectant
- Sodium Hyaluronate is the salt of hyaluronic acid, and it is what most products labelled hyaluronic actually contain. The salt dissolves more readily and the molecule is smaller, so it sits in the outer layer of skin rather than only on top of it.
- Polyglyceryl-6 Laurate emulsifier
- Six glycerin units joined to lauric acid. Polyglyceryl esters are the mild, PEG-free way to hold oil and water together.
- Polyglutamic Acid humectant
- Polyglutamic Acid comes from fermented soy and holds several times more water than hyaluronic acid for its weight. It forms a light film on the surface, so it is often layered with hyaluronic rather than replacing it.
- Myristyl Glucoside surfactant
- A sugar surfactant with a slightly longer fatty chain than lauryl glucoside, so it feels a little richer. It carries no charge and is mild.
- Disodium EDTA chelator
- EDTA is a chelator: it locks up trace metal ions from water and packaging that would otherwise turn a formula cloudy, off-colour or rancid. It does nothing to skin and appears at a fraction of a percent.
- Ceramide NP barrier lipid
- Ceramide NP is the most used cosmetic ceramide, the same class of lipid that makes up roughly half the mortar between cells in the outer layer of skin. Added to a cream it slots into that structure, which is why ceramide formulas feel less leaky rather than merely greasy.
- Glyceryl Acrylate/Acrylic Acid Copolymer film former
- This is a polymer that forms a moisture-holding film on the surface, usually supplied with glycerin and propylene glycol as a hydrating complex.
- Madecassoside active
- Madecassoside is the centella triterpene most associated with the look of redness, and the one brands lead with in cica products. It is water soluble and stable, so it appears in essences as readily as in creams.
- Stearic Acid fatty acid
- Stearic Acid is a saturated fatty acid from plant fats, and one of the three lipid classes skin's own barrier is built from. In a formula it thickens, stabilises the emulsion and can be turned into a soap-style cleanser by adding a base.
- PVM/MA Copolymer film former
- PVM/MA Copolymer is a film-forming polymer used to hold a formula in place and, in a mask, to give the peel-off film its strength.
- Honokiol antioxidant
- Honokiol is a biphenyl compound from magnolia bark, one of the two the bark is best known for. It is oil soluble and used as a plant antioxidant.
- Rosmarinus Officinalis (Rosemary) Extract plant extract
- Rosemary extract with the plant part unstated. Rosemary carries rosmarinic and carnosic acid, and it is also used to keep the oils in a formula from going rancid.
- Oleic Acid fatty acid
- Oleic Acid is the main fatty acid in olive and many nut oils. It is a rich emollient that softens skin and can feel heavy on skin prone to congestion.
- Centella Asiatica Extract plant extract
- Centella Asiatica is the plant behind the whole cica category, sold as gotu kola or Madagascar centella. Its extract is the anchor of Korean formulas built for easily reddened skin, and its work is done by four triterpenes: asiaticoside, madecassoside, asiatic acid and madecassic acid.
- Caprylyl Glycol preservative booster
- Caprylyl Glycol is a glycol that conditions skin and, more importantly, strengthens a preservative system so less of the traditional preservative is needed. It appears in most modern formulas built without parabens.
- Butylene Glycol humectant
- Butylene Glycol is a small glycol that does two jobs at once: it holds water in the top layer of skin and it dissolves plant extracts and actives that plain water cannot. It also thins a formula, which is why watery Korean essences lean on it.
- Sodium DNA active
- Sodium DNA is the salt of DNA, in Korean skincare almost always salmon derived, and it is the ingredient behind the PDRN category. It is used as a humectant and for the look of tired skin; the fragments themselves are what the name PDRN refers to.
- Limonene fragrance component
- Limonene is the citrus-peel aromatic. It appears here because EU labelling requires 26 fragrance components to be named individually rather than hidden inside "fragrance", and it is one of them.
- Pinene fragrance component
- Pinene is the terpene that makes pine and rosemary smell the way they do. On a label it is an aromatic plant constituent rather than a functional ingredient.
- Market
- Korean market, the version sold in Korea
- EAN (barcode)
- 8809670683429
- Made in
- Republic of Korea
- Volume
- 15 g
- Category
- Serum & Ampoule
- Actives
- Allantoin, Azelaic Acid, Centella Asiatica, Ceramide NP, Madecassoside, Niacinamide, Panthenol, PDRN (Sodium DNA), Salicylic Acid, Shea Butter, Sodium Hyaluronate, Tea Tree, Zinc PCA
- Ships from
- California or Korea
Orders ship from California or direct from Korea with tracked delivery to your door, and both routes carry the same Korean-market release. Shipping is free on orders of $100 or more. Returns are accepted for 30 days, by mail.
We split shipments free, so one out-of-stock item never holds up the rest of your order.
Where this unit came from
- 1Seoul
Bought as Korean-market stock - 2Barcode
Listed against the Korean barcode on its box - 3California or Korea
Ships to you from either, as the same Korean-market release
We stock the version of a formula that is sold in Korea, not the release a brand prepares for another market under the same name. The barcode in the specification above is the Korean-market one and it is printed on the box you receive.
Every unit keeps its original barcode and batch code intact, so the unit in your hands can be checked against the brand’s own records.
Every order ships from California or direct from Korea, and returns run for 30 days.
Every claim on this page traces to the unit in the box, the barcode, the batch code and the price you can read for yourself.
How to use
- Use the Spicule Azelaic PDRN Spot Cream after toner and before moisturizer, in the evening.
- Apply an even layer of Mary&May Spicule Azelaic PDRN Spot Cream across your face. Follow your skin's natural texture and gently press in the cream with your palms to help absorption. If it's your first time using this face cream, start by applying it in the evening, 2 to 3 times a week. You can gradually increase to daily use.
- Toner first so the surface is damp, then this, then about a minute before your moisturizer goes over the top.
- Twice a day, every day. Do not stack it with a second serum of the same kind; two hydrating serums in one routine do the work of one.
Worth knowing
- Patch test on the inner arm before first full use, as with any new skincare product.
- Introduce a new active gradually into an existing routine rather than adding several at once.
Complete the routine
- This itemMary & May Spicule Azelaic PDRN Spot Cream$9.40
- Seal the routine in as the last stepMary & May Sensitive Soothing Gel Cream 100g$30.00
- The treatment step of this routineMary & May Centella Asiatica Serum 30ml$20.00
Total for 3 items$59.40
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Mary & May Spicule Azelaic PDRN Spot Cream
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Mary & May, Korean-market original
Mary & May's Spicule Azelaic PDRN Spot Cream, sourced for the Korean market.
Verify your unit when it arrives
Verify your unit when it arrives
Korean-market stock with the original barcode and batch code intact, exactly as it left Korea.
On the unit itself
- The Korean-market barcode, unaltered from the retail package.
- The manufacturer’s batch code, exactly as the maker printed it.
정품Genuine article, Korean-market stock
What professionals say
What professionals say
What skin-care professionals say about skin care, quoted from the medical sources linked beside each.
Your skin barrier is basically your outer layer of the skin.
Melissa Piliang, MDDermatologist, Cleveland Clinic Pretty much every step of a Korean skin care routine is going to have some component of hydration.
Alok Vij, MDDermatologist, Cleveland Clinic
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