Where does Dermalogy High R Exosome Cream go in a routine?

It goes last, after your toner, essence or serum, since a cream is a sealing step rather than a treatment one. Applying it before a thinner step blocks that step from reaching the skin at all.

How much should I use?

A small amount, roughly a fingertip's worth, warmed between the fingers first so it spreads evenly rather than sitting in patches. As with any new step, give it a fair, consistent trial of a week or two before you decide whether to keep it in your routine, and stop if you notice ongoing irritation rather than pushing through it.

Is this the same formula sold in Korea, or a version made for the US market?

This is the Korean-market formula, the same one sold on shelves in Korea rather than a version reformulated for US retail.

Can I use this if my skin runs sensitive?

This cream is formulated with skin types like normal or dry skin in mind, but any new product is worth a patch test first if your skin reacts easily. A short patch test on the inside of your arm or behind an ear before it goes on your face is worth doing, and that goes for sensitive skin most of all.

How long before I will know if this is right for my skin?

Give it a full week or two of consistent use before you judge, since a single use rarely tells you much either way. Watch for how skin feels and looks rather than for any specific number, and stop use if you notice ongoing irritation.

NEOGEN

Dermalogy High R Exosome Cream 40ml

Name: NEOGEN Dermalogy High R Exosome Cream 40ml
Brand: NEOGEN
SKU: 6576760613
Price: 25.0 USD
Availability: InStock

NEOGEN Dermalogy High R Exosome Cream is an exosome-infused cream, the final leave-on step of a routine for anyone who wants their treatment steps sealed in.

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$25.00

40 ml

Ships from California or direct from Korea
Korean barcode and batch code intact

Suited to: Normal skinDry skinCombination skin

Helps with: Sealing in earlier serum or essence stepsA finishing moisture layerA step that is easy to build a consistent routine around

In stock. Ships from California or direct from Korea

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Key benefits

Glycerin sits right near the top of the 93-ingredient list, a foundational humectant that draws in and holds surface moisture
Niacinamide sits right near the top of the 93-ingredient list, a tone-evening ingredient that works on visible unevenness and surface texture
Adenosine sits early in the 93-ingredient list, a smoothing ingredient long used in Korean formulas to soften the look of fine lines
Theobroma Cacao (Cocoa) Extract sits early in the 93-ingredient list, a cocoa-derived ingredient carried for its cushioning, moisture-sealing feel
Formulated as a cream from NEOGEN, sized for regular use in a routine
Comes in a 40ml format, sized for the moisturizing step of a routine

Key actives

5Niacinamide

A brightening and barrier-supporting vitamin B3 derivative used widely in Korean formulas, chosen for a more even, comfortable-feeling surface rather than for any single dramatic overnight change.

17Adenosine

A soothing, skin-conditioning ingredient common in Korean ampoules and creams, included at a cosmetic level meant to calm and condition the surface rather than to correct anything medically.

21Centella Asiatica

A cica extract long used in Korean skincare for its calming, skin-conditioning reputation, chosen for stressed or reactive-feeling skin that wants a gentler formula in its routine.

64Hyaluronate

A water-binding humectant that helps the surface feel plumper and less tight through the day, one of the most common hydration ingredients in Korean formulas of every kind.

87Hyaluronic Acid

A water-binding humectant that helps the surface feel plumper and less tight through the day, one of the most common hydration ingredients in Korean formulas of every kind.

Inside the formula

Ingredients declared

No fragrance

on the list

5Niacinamide17Adenosine64Hyaluronate87Hyaluronic Acid

5Niacinamide
17Adenosine
64Hyaluronate
87Hyaluronic Acid

Where each key active sits on the declared ingredient list, by entry number. Position is proportion: the further forward, the larger its share.

1 of 3

89 of 92 explained

Water solvent: Water is the base almost every serum, toner and cream is built on. It dissolves the water-loving ingredients and sets how light the finished texture feels. On an INCI list it is usually first, which only means it is the largest single ingredient by weight.
Glycerin humectant: Glycerin is the most used humectant in skincare. It draws water into the outer layer of skin and holds it there, and it is one of the very few ingredients whose hydrating effect is settled science rather than marketing. Higher amounts feel tacky, which is why it is usually blended.
Propanediol humectant: Propanediol is a plant-derived glycol used in place of propylene glycol. It hydrates, carries actives into solution, and gives a lighter, less sticky slip than glycerin at the same strength.
Butylene Glycol humectant: Butylene Glycol is a small glycol that does two jobs at once: it holds water in the top layer of skin and it dissolves plant extracts and actives that plain water cannot. It also thins a formula, which is why watery Korean essences lean on it.
Niacinamide active: Niacinamide is vitamin B3, and it is the most studied active in Korean formulation. It is used at roughly 2 to 5 percent for the look of uneven tone and visible pores, and it is water soluble, stable and comfortable beside almost every other active, which is why it turns up in so many lists.
Isononyl Isononanoate emollient: Isononyl Isononanoate is a branched ester used as a dry emollient. It spreads far for its weight and leaves almost no residue, which is why it appears in formulas that have to feel weightless.
1,2-Hexanediol humectant: 1,2-Hexanediol is a glycol used for two reasons: it holds water like glycerin, and it makes a formula harder for microbes to live in, so less traditional preservative is needed. Korean formulas use it heavily for that second reason.
C13-16 Isoalkane emollient: A light branched hydrocarbon used as a spreading agent. It thins a formula, carries pigments evenly and leaves a dry finish.
Ammonium Acryloyldimethyltaurate/VP Copolymer thickener: This is a synthetic thickener that gels quickly and holds an emulsion stable across a wide pH range. It gives a light, non-tacky body.
Cetearyl Olivate emulsifier: Cetearyl Olivate is the water-loving half of the olive-derived emulsifier pair. With sorbitan olivate it builds emulsions whose lipid profile is close to skin's own.
Heptyl Undecylenate emollient: A plant-derived ester used as a light, dry emollient and as a solvent for oil-soluble ingredients. Formulas that avoid silicones use it for the same slip.
Sorbitan Olivate emulsifier: Sorbitan Olivate is an olive-derived emulsifier, the oil-loving half of the pair sold as Olivem. It holds oil into water and leaves a light, non-waxy feel.

77 more explained

Xanthan Gum thickener: Xanthan Gum is a polysaccharide made by fermenting sugar. It thickens a watery formula into a gel and holds the whole thing in suspension so nothing separates. Too much of it and a serum turns stringy, which is why it appears in fractions of a percent.
Acrylates/C10-30 Alkyl Acrylate Crosspolymer thickener: This is a carbomer relative with fatty side chains, so it thickens and stabilises an emulsion at the same time. It gives a light gel-cream body rather than a heavy one.
Ethylhexylglycerin preservative booster: Ethylhexylglycerin softens skin and boosts a preservative system, which is why it is nearly always sitting beside phenoxyethanol or 1,2-hexanediol. It also cuts down the odour bacteria produce, so it turns up in deodorising products.
Glyceryl Acrylate/Acrylic Acid Copolymer film former: This is a polymer that forms a moisture-holding film on the surface, usually supplied with glycerin and propylene glycol as a hydrating complex.
Adenosine active: Adenosine is a nucleoside that Korea's own cosmetic authority recognises as a wrinkle-care functional ingredient, which is why it appears on so many Korean lists at a low level. It is used for the look of fine lines and is stable and well tolerated.
Tromethamine pH adjuster: Tromethamine neutralises acidic thickeners such as carbomer so they gel, and holds a formula near skin-friendly pH. It is used at a fraction of a percent.
Dextrin thickener: Dextrin is a starch fragment used to thicken and to give a formula a light, powdery finish. It is also a common carrier for powdered extracts.
Theobroma Cacao (Cocoa) Extract plant extract: Cocoa Extract carries polyphenols and a little caffeine. It is used as an antioxidant plant extract and gives a faint warm tint.
Centella Asiatica Leaf Extract plant extract: Centella Asiatica is the plant behind the whole cica category, sold as gotu kola or Madagascar centella. Its extract is the anchor of Korean formulas built for easily reddened skin, and its work is done by four triterpenes: asiaticoside, madecassoside, asiatic acid and madecassic acid.
Sodium PCA humectant: Sodium PCA is one of the substances skin makes for itself to hold water, part of what dermatology calls the natural moisturising factor. Added to a formula it is a strong humectant that suits skin that dehydrates quickly.
Sodium Lactate humectant: Sodium Lactate is the salt of lactic acid and one of the components of skin's own natural moisturising factor. At the levels used here it is a humectant and buffer rather than an exfoliant.
Maltodextrin film former: Maltodextrin is a starch-derived sugar chain used to carry powdered extracts and to form a light film. It also gives a soft, smoothing feel.
Ascorbic Acid antioxidant: Ascorbic Acid is pure vitamin C, the most researched form and also the least stable: it needs a low pH and airtight packaging to stay active. It is an antioxidant used for the look of dullness and uneven tone.
Magnesium Ascorbyl Phosphate antioxidant: Magnesium Ascorbyl Phosphate is a stable, water-soluble vitamin C salt. It works at a near-neutral pH, so it suits formulas built for skin that finds pure ascorbic acid stinging.
Ascorbyl Tetraisopalmitate antioxidant: Ascorbyl Tetraisopalmitate is an oil-soluble vitamin C ester, also sold as tetrahexyldecyl ascorbate. Being oil soluble it sits in the oil phase and is far more stable than pure vitamin C.
Ferulic Acid antioxidant: Ferulic Acid is a plant antioxidant from bran and seeds. Its main formulation job is stabilising vitamins C and E so a serum keeps working for longer, which is why the three appear together so often.
Arginine amino acid: Arginine is an amino acid that does two jobs here: it holds water in the outer layer of skin, and it neutralises acidic gelling agents, which is why it often stands in for a synthetic pH adjuster.
Aspartic Acid amino acid: Aspartic Acid is an amino acid used as a humectant and buffer, usually within a wider amino acid blend.
Pca humectant: PCA is pyrrolidone carboxylic acid, one of the components of the natural moisturising factor skin makes for itself. It holds water at the surface, and its salts do the same job.
Hydrogenated Lecithin emulsifier: Hydrogenated Lecithin is lecithin with its unsaturated bonds filled in, which makes it far more stable. It emulsifies and is the standard shell for the liposomes that carry actives into the outer layer of skin.
Sodium Starch Octenylsuccinate absorbent: Modified starch used as a very soft powder. It absorbs oil, blurs the look of texture, and takes the shine off a formula.
Caprylic/Capric Triglyceride emollient: Caprylic/Capric Triglyceride is the light fraction of coconut oil, with the heavy parts removed. It is the workhorse emollient of modern formulas: it softens skin, dissolves oil-soluble actives and absorbs without the greasy weight of a whole plant oil.
Polyglyceryl-10 Laurate emulsifier: Polyglyceryl-10 Laurate is a sugar-derived emulsifier and solubiliser, mild enough to be a standard choice in Korean essences. It dissolves small amounts of oil into water without any tightening feel.
Calcium Pantothenate vitamin: Calcium Pantothenate is the calcium salt of pantothenic acid, vitamin B5. It is the salt form of the same vitamin panthenol converts to, and it hydrates and conditions.
Glycine amino acid: Glycine is the smallest amino acid and one of the free amino acids skin holds to keep water in the outer layer. In a formula it is a humectant and a mild buffer.
Alanine amino acid: Alanine is a free amino acid skin uses as part of its own moisture-holding system. In a formula it hydrates and conditions.
Sodium Ascorbyl Phosphate antioxidant: Sodium Ascorbyl Phosphate is a water-soluble, stable vitamin C salt. It works at near-neutral pH, so it appears in formulas aimed at skin that pure ascorbic acid leaves stinging.
Lecithin emulsifier: Lecithin is a soy or sunflower-derived phospholipid, the same class of molecule cell membranes are built from. It emulsifies oil into water and is the basis of the liposomes formulators use to carry actives.
Panthenol humectant: Panthenol is pro-vitamin B5: skin converts it to pantothenic acid. It is a humectant that holds water and leaves skin feeling soft and less tight, and it is one of the ingredients formulators reach for when a formula also contains something harsh.
Polysorbate 20 emulsifier: Polysorbate 20 is a solubiliser: it dissolves small amounts of oil or fragrance into a watery formula so nothing separates or floats.
Palmitic Acid fatty acid: Palmitic Acid is a saturated fatty acid present in skin's own lipids. It thickens a formula, stabilises the emulsion and softens skin.
Serine amino acid: Serine is one of the most abundant free amino acids in the outer layer of skin, where it helps hold water. Added to a formula it is a humectant.
Valine amino acid: Valine is an essential amino acid used as a humectant alongside the rest of an amino acid block.
Resveratrol antioxidant: Resveratrol is an antioxidant from grape skin and Japanese knotweed. It is used for the look of dullness and is often paired with ferulic acid, which keeps it stable.
Caprylyl Glycol preservative booster: Caprylyl Glycol is a glycol that conditions skin and, more importantly, strengthens a preservative system so less of the traditional preservative is needed. It appears in most modern formulas built without parabens.
Isoleucine amino acid: Isoleucine is an essential amino acid used as a conditioning humectant within an amino acid complex.
Threonine amino acid: Threonine is an essential amino acid used in skincare as a humectant, normally as part of an amino acid complex rather than alone.
Proline amino acid: Proline is an amino acid abundant in collagen and one of skin's own humectants. Added to a formula it holds water in the outer layer.
Gardenia Florida Fruit Extract plant extract: Gardenia Fruit Extract is the traditional East Asian yellow dye plant. In skincare it is used as an antioxidant extract, and it can tint a formula.
Sodium Polyphosphate chelator: Sodium Polyphosphate is a chain phosphate salt that ties up metal ions. That keeps a formula stable and stops hard water flattening a cleanser foam.
Tocopheryl Acetate antioxidant: Tocopheryl Acetate is a stable vitamin E ester that skin converts to tocopherol. It is used as an antioxidant and a light emollient and holds up better than plain vitamin E in a formula.
Pyridoxine Hcl vitamin: Pyridoxine HCl is the water-soluble salt of vitamin B6. It is a conditioning vitamin, most often part of a B-complex blend.
Phenylalanine amino acid: Phenylalanine is an essential amino acid used in skincare as a conditioning humectant.
Histidine amino acid: Histidine is an amino acid used as a humectant and a buffer, part of skin's own free amino acid pool.
Sodium Ascorbate vitamin: The sodium salt of vitamin C. It is less acidic than pure ascorbic acid and dissolves readily in water, though like ascorbic acid it still oxidises once in solution.
Palmitoyl Tripeptide-5 peptide: Palmitoyl Tripeptide-5 is a fatted three-amino-acid peptide used for the look of firmness and fine lines. The palmitoyl tail is what lets it cross an oily surface.
Glucose humectant: Glucose is a simple sugar used as a humectant and as food for the ferment ingredients in the same formula. It hydrates mildly and adds a soft slip.
Dipeptide Diaminobutyroyl Benzylamide Diacetate peptide: This is a two-amino-acid peptide, sold as Syn-Ake, used for the look of expression lines. Its structure was modelled on a component of snake venom, though nothing of the venom itself is in it.
Disodium EDTA chelator: EDTA is a chelator: it locks up trace metal ions from water and packaging that would otherwise turn a formula cloudy, off-colour or rancid. It does nothing to skin and appears at a fraction of a percent.
Sodium Hyaluronate humectant: Sodium Hyaluronate is the salt of hyaluronic acid, and it is what most products labelled hyaluronic actually contain. The salt dissolves more readily and the molecule is smaller, so it sits in the outer layer of skin rather than only on top of it.
Silica absorbent: Silica is finely milled mineral, essentially very pure sand. It absorbs oil, stops powders clumping and soft-focuses the look of pores and fine lines.
Copper Tripeptide-1 peptide: Copper Tripeptide-1 is three amino acids bound to a copper ion, and the classic firming peptide in cosmetic chemistry. It is blue in solution, which is often why a serum carrying it is tinted, and it is used for the look of firmness and fine lines.
Chondrus Crispus Extract plant extract: Chondrus Crispus is Irish moss, a red seaweed. It is loaded with carrageenan, so it hydrates and thickens at once, and it leaves a cushioned, slippery film.
Biotin vitamin: Biotin is vitamin B7. In skincare it is a conditioning vitamin, most often in hair and scalp formulas.
Pyridoxine vitamin: Pyridoxine is vitamin B6. In a formula it is a conditioning vitamin, most often in B-complex blends and scalp products.
Folic Acid vitamin: Folic Acid is vitamin B9. It is used in a formula as a conditioning vitamin, usually as part of a B-complex blend.
Hydroxypropyltrimonium Hyaluronate humectant: Hydroxypropyltrimonium Hyaluronate carries a positive charge, and skin carries a slight negative one, so it is attracted to the surface and stays through rinsing. It is the hyaluronic used where a formula gets washed off.
Cyanocobalamin vitamin: Cyanocobalamin is vitamin B12, and it is a deep pink-red, which is why a formula carrying it often has a colour nobody added on purpose. It is used as a conditioning vitamin.
Tocopherol antioxidant: Tocopherol is vitamin E. It is an oil-soluble antioxidant that protects the oils in a formula from going rancid and works on skin as an emollient, and it is regularly paired with vitamin C because each keeps the other going for longer.
Tripeptide-1 peptide: Tripeptide-1 is the copper-free version of the classic three-amino-acid peptide. It is used for the look of firmness in formulas that avoid copper's blue tint.
Hydrolyzed Hyaluronic Acid humectant: Hydrolyzed Hyaluronic Acid is hyaluronic acid cut into much shorter fragments. The smaller the fragment, the further into the outer layer it can settle, which is why serums stack several sizes together instead of using one.
Sodium Acetylated Hyaluronate humectant: Sodium Acetylated Hyaluronate is hyaluronic acid modified to be part oil-loving, so it clings to skin instead of rinsing away. Formulators call it the one that stays put.
Riboflavin vitamin: Riboflavin is vitamin B2, and it is a strong yellow, so a formula carrying it often has a colour nobody added on purpose.
Thiamine Hcl vitamin: Thiamine is vitamin B1, supplied as its hydrochloride salt so it dissolves in water. It is a conditioning vitamin and usually appears as part of a B-complex.
Palmitoyl Tripeptide-1 peptide: Palmitoyl Tripeptide-1 is a short peptide with a fatty tail added so it can travel through the oily outer layer of skin. It is used for the look of firmness and is almost always paired with palmitoyl tetrapeptide-7.
Linoleic Acid fatty acid: Linoleic Acid is an essential omega-6 fatty acid and the main fatty acid in sunflower, safflower and rosehip oil. In a formula it is a lipid that softens and sits in the outer layer.
Tripeptide-2 peptide: Tripeptide-2 is a peptide of three amino acids. The number after the name identifies one specific sequence rather than a strength, and it is used in blends for the look of firmness.
Hexapeptide-11 peptide: Hexapeptide-11 is a yeast-derived six-amino-acid peptide used for the look of resilience and firmness.
Beta-Carotene antioxidant: Beta-Carotene is an orange plant pigment and a vitamin A precursor. It is used as an antioxidant and it tints a formula, which is often why it is there.
Acetyl Hexapeptide-8 peptide: Acetyl Hexapeptide-8 is a six-amino-acid peptide used for the look of expression lines, particularly around the eyes. It is the peptide sold under the name Argireline and is water soluble and stable.
Palmitoyl Tetrapeptide-7 peptide: Palmitoyl Tetrapeptide-7 is a four-amino-acid peptide with a fatty tail, used for the look of fine lines. With palmitoyl tripeptide-1 it forms the pairing sold as Matrixyl 3000.
Palmitoyl Pentapeptide-4 peptide: Palmitoyl Pentapeptide-4 is the five-amino-acid peptide originally sold as Matrixyl. It is used for the look of fine lines and is one of the longest-standing cosmetic peptides.
Hyaluronic Acid humectant: Hyaluronic Acid is a sugar chain the body already makes, and one gram of it can hold several litres of water. In a formula it is a humectant that pulls water to the surface of skin and holds it in a film, which is what makes skin look plumper while it is there.
Hexapeptide-9 peptide: Hexapeptide-9 is a six-amino-acid peptide used for the look of firmness and elasticity. It is water soluble and appears in peptide blends rather than alone.
Nonapeptide-1 peptide: Nonapeptide-1 is a nine-amino-acid peptide used for the look of uneven tone rather than for firmness, which makes it unusual among cosmetic peptides.
Sodium Hyaluronate Crosspolymer humectant: Sodium Hyaluronate Crosspolymer is hyaluronic acid linked into a mesh. It holds water in a soft gel on the surface rather than sinking in, and it releases that water slowly through the day.
Potassium Hyaluronate humectant: Potassium Hyaluronate is another salt of hyaluronic acid, used for the same reason as the sodium form: it dissolves easily and holds a large amount of water in the outer layer of skin.

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How it works

A cream is the last leave-on layer in a Korean routine, staying on the surface to slow water loss rather than absorbing deep and disappearing. It goes on after every thinner step, since a cream applied first blocks a toner or serum from reaching the skin at all. What it can be judged on is how the face feels a few hours later rather than immediately after applying it. Consistency across days does more for a fair read than any single application, since a genuine change in how skin looks or feels builds gradually rather than all at once. It is the version sold on shelves in Korea rather than a formula reworked for a different market.

How to use

Use the Dermalogy High R Exosome Cream as the last skincare step, morning and evening, over serum.
In the last step of your morning and evening routines, apply the cream on face and gently massage skin to aid absorption.
It closes the routine at night, and in the morning it is the layer sunscreen goes over.
Twice a day. Do not skip it on an oily day; without a sealing layer the water the steps beneath it brought in leaves again.

Worth knowing

Patch test on the jaw first if your skin reacts easily to something new.
Very oily skin may prefer a thinner layer or a lighter product in summer.

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NEOGEN Dermalogy High R Exosome Cream 40ml

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NEOGEN, Korean-market original

NEOGEN Dermalogy High R Exosome Cream, cream with Glycerin, 40ml, Korean-market formula.

Verify your unit when it arrives

Korean-market stock with the original barcode and batch code intact, exactly as it left Korea.

On the unit itself

The Korean-market barcode, unaltered from the retail package.
The manufacturer’s batch code, exactly as the maker printed it.

정품Genuine article, Korean-market stock

What professionals say

What skin-care professionals say about the key actives in this formula, quoted from the medical sources linked beside each.

Centella can make your skin appear more hydrated, plumper and healthier.
Samantha Stein, PA-CDermatology physician assistant, Cleveland Clinic
Niacinamide helps reduce the appearance of pores in a few ways. By strengthening the skin barrier and improving elasticity, pores appear less noticeable and more even.
Ashlyn YankeAesthetician, Cleveland Clinic